Malaria infection among adults residing in a highly endemic region from the Democratic Republic of the Congo.

Autor: Kayiba NK; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Public Health, Faculty of Medicine - Pharmacy and Public Health, University of Mbujimayi, Mbuji Mayi, Democratic Republic of Congo.; Research Institute of Health and Society, Université Catholique de Louvain, Brussels, Belgium., Nitahara Y; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Tshibangu-Kabamba E; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Internal Medicine, Faculty of Medicine - Pharmacy and Public Health, University of Mbujimayi, Mbuji Mayi, Democratic Republic of Congo., Mbuyi DK; Department of Internal Medicine, Faculty of Medicine - Pharmacy and Public Health, University of Mbujimayi, Mbuji Mayi, Democratic Republic of Congo., Kabongo-Tshibaka A; Department of Internal Medicine, Faculty of Medicine - Pharmacy and Public Health, University of Mbujimayi, Mbuji Mayi, Democratic Republic of Congo.; Department of Molecular Infection Dynamics, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan., Kalala NT; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Public Health, Faculty of Medicine - Pharmacy and Public Health, University of Mbujimayi, Mbuji Mayi, Democratic Republic of Congo., Tshiebue BM; Department of Internal Medicine, Faculty of Medicine - Pharmacy and Public Health, University of Mbujimayi, Mbuji Mayi, Democratic Republic of Congo., Candray-Medina KS; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Kaku N; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Nakagama Y; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan., Speybroeck N; Research Institute of Health and Society, Université Catholique de Louvain, Brussels, Belgium., Mumba DN; Department of Parasitology, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of Congo., Disashi GT; Department of Internal Medicine, Faculty of Medicine - Pharmacy and Public Health, University of Mbujimayi, Mbuji Mayi, Democratic Republic of Congo., Kaneko A; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Kido Y; Research Center for Infectious Disease Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. kidoyasu@omu.ac.jp.; Departments of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan. kidoyasu@omu.ac.jp.
Jazyk: angličtina
Zdroj: Malaria journal [Malar J] 2024 Mar 18; Vol. 23 (1), pp. 82. Date of Electronic Publication: 2024 Mar 18.
DOI: 10.1186/s12936-024-04881-7
Abstrakt: Background: Adults infected with Plasmodium spp. in endemic areas need to be re-evaluated in light of global malaria elimination goals. They potentially undermine malaria interventions but remain an overlooked aspect of public health strategies.
Methods: This study aimed to estimate the prevalence of Plasmodium spp. infections, to identify underlying parasite species, and to assess predicting factors among adults residing in an endemic area from the Democratic Republic of Congo (DRC). A community-based cross-sectional survey in subjects aged 18 years and above was therefore carried out. Study participants were interviewed using a standard questionnaire and tested for Plasmodium spp. using a rapid diagnostic test and a nested polymerase chain reaction assay. Logistic regression models were fitted to assess the effect of potential predictive factors for infections with different Plasmodium spp.
Results: Overall, 420 adults with an estimated prevalence of Plasmodium spp. infections of 60.2% [95% CI 55.5; 64.8] were included. Non-falciparum species infected 26.2% [95% CI 22.2; 30.5] of the study population. Among infected participants, three parasite species were identified, including Plasmodium falciparum (88.5%), Plasmodium malariae (39.9%), and Plasmodium ovale (7.5%) but no Plasmodium vivax. Mixed species accounted for 42.3% of infections while single-species infections predominated with P. falciparum (56.5%) among infected participants. All infected participants were asymptomatic at the time of the survey. Adults belonging to the "most economically disadvantaged" households had increased risks of infections with any Plasmodium spp. (adjusted odds ratio, aOR = 2.87 [95% CI 1.66, 20.07]; p < 0.001), compared to those from the "less economically disadvantaged" households. Conversely, each 1 year increase in age reduced the risk of infections with any Plasmodium spp. (aOR = 0.99 [95% CI 0.97, 0.99]; p = 0.048). Specifically for non-falciparum spp., males had increased risks of infection than females (aOR = 1.83 [95% CI 1.13, 2.96]; p = 0.014).
Conclusion: Adults infected with malaria constitute a potentially important latent reservoir for the transmission of the disease in the study setting. They should specifically be taken into account in public health measures and translational research.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje