Abnormal phosphorylation / dephosphorylation and Ca 2+ dysfunction in heart failure.

Autor: Liu YB; Interventional Medical Center, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China.; Medical College, Qingdao University, Qingdao, China., Wang Q; Medical College, Qingdao University, Qingdao, China., Song YL; Department of Pediatrics, Huantai County Hospital of Traditional Chinese Medicine, Zibo, China., Song XM; Medical College, Qingdao University, Qingdao, China., Fan YC; Medical College, Qingdao University, Qingdao, China., Kong L; Medical College, Qingdao University, Qingdao, China., Zhang JS; Medical College, Qingdao University, Qingdao, China., Li S; Medical College, Qingdao University, Qingdao, China., Lv YJ; Medical College, Qingdao University, Qingdao, China., Li ZY; Medical College, Qingdao University, Qingdao, China., Dai JY; Department of Oncology, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China. dr_djy@126.com., Qiu ZK; Interventional Medical Center, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266003, Shandong Province, China. dr_qiuzk@126.com.
Jazyk: angličtina
Zdroj: Heart failure reviews [Heart Fail Rev] 2024 Jul; Vol. 29 (4), pp. 751-768. Date of Electronic Publication: 2024 Mar 18.
DOI: 10.1007/s10741-024-10395-w
Abstrakt: Heart failure (HF) can be caused by a variety of causes characterized by abnormal myocardial systole and diastole. Ca 2+ current through the L-type calcium channel (LTCC) on the membrane is the initial trigger signal for a cardiac cycle. Declined systole and diastole in HF are associated with dysfunction of myocardial Ca 2+ function. This disorder can be correlated with unbalanced levels of phosphorylation / dephosphorylation of LTCC, endoplasmic reticulum (ER), and myofilament. Kinase and phosphatase activity changes along with HF progress, resulting in phased changes in the degree of phosphorylation / dephosphorylation. It is important to realize the phosphorylation / dephosphorylation differences between a normal and a failing heart. This review focuses on phosphorylation / dephosphorylation changes in the progression of HF and summarizes the effects of phosphorylation / dephosphorylation of LTCC, ER function, and myofilament function in normal conditions and HF based on previous experiments and clinical research. Also, we summarize current therapeutic methods based on abnormal phosphorylation / dephosphorylation and clarify potential therapeutic directions.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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