The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma.

Autor: Song CY; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan., Wu CY; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.; Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan.; Department of Neurosurgery, China Medical University Hsinchu Hospital, Hsinchu, Taiwan., Lin CY; Translational Medicine Center, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan., Tsai CH; Department of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan.; Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan., Chen HT; Department of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan.; Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan., Fong YC; Department of Sports Medicine, College of Health Care, China Medical University, Taichung, Taiwan.; Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan.; Department of Orthopedic Surgery, China Medical University Beigang Hospital, Taichung, Yunlin, Taiwan., Chen LC; Department of Pharmacy, Tajen University, Pingtung, Taiwan., Tang CH; Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan.; Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan.; Department of Medical Laboratory Science and Biotechnology, College of Medical and Health Science, Asia University, Taichung, Taiwan.; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.; Department of Medical Research, China Medical University Hsinchu Hospital, Hsinchu, Taiwan.
Jazyk: angličtina
Zdroj: Environmental toxicology [Environ Toxicol] 2024 Jul; Vol. 39 (7), pp. 3790-3798. Date of Electronic Publication: 2024 Mar 18.
DOI: 10.1002/tox.24236
Abstrakt: Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous tissue and is associated with lung metastases. Extracellular vesicles called exosomes are primarily used as mediators of intercellular signal transmission to control tumor metastasis. Visfatin is an adipokine reported to enhance tumor metastasis, but its relationship with exosome generation in chondrosarcoma motility remains undetermined. Our results found that overexpressing visfatin augments the production of exosomes from chondrosarcoma cells. Visfatin-treated chondrosarcoma exosomes educate macrophage polarization towards the M2 but not M1 phenotype. Interestingly, M2 macrophages polarized by exosomes return to chondrosarcoma cells to facilitate cell motility. According to these findings, chondrosarcoma cells emit more exosomes when treated with visfatin. The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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