Transient Abnormal Myelopoiesis: An Abnormal Course and the Efficacy of Delayed Treatment.

Autor:	Mishra P; Neonatology, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND., Fajrudheen M; Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND., Sahoo T; Neonatology, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND., Som TK; Neonatology, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND., Biswal S; Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND., Chhabra G; Pathology, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Feb 14; Vol. 16 (2), pp. e54219. Date of Electronic Publication: 2024 Feb 14 (Print Publication: 2024).
DOI:	10.7759/cureus.54219
Abstrakt:	Transient abnormal myelopoiesis (TAM) is observed in a few neonates with Down syndrome. While a large proportion undergo complete remission without any treatment, some of them can develop myeloid leukemia of Down syndrome (ML-DS) in the future. Without proper treatment, mortality can be high. Here we have described an interesting and difficult-to-treat case of a neonatal with Down syndrome who presented with anemia, thrombocytopenia, and 75% blasts. We came across multiple challenges in treatment due to severe pneumonia. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Mishra et al.)
Databáze:	MEDLINE
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