Heterogeneity of chemical modifications on RNA.

Autor: Goh WSS; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China., Kuang Y; Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.
Jazyk: angličtina
Zdroj: Biophysical reviews [Biophys Rev] 2023 Oct 17; Vol. 16 (1), pp. 79-87. Date of Electronic Publication: 2023 Oct 17 (Print Publication: 2024).
DOI: 10.1007/s12551-023-01128-8
Abstrakt: The chemical modifications of RNAs broadly impact almost all cellular events and influence various diseases. The rapid advance of sequencing and other technologies opened the door to global methods for profiling all RNA modifications, namely the "epitranscriptome." The mapping of epitranscriptomes in different cells and tissues unveiled that RNA modifications exhibit extensive heterogeneity, in type, amount, and in location. In this mini review, we first introduce the current understanding of modifications on major types of RNAs and the methods that enabled their discovery. We next discuss the tissue and cell heterogeneity of RNA modifications and briefly address the limitations of current technologies. With much still remaining unknown, the development of the epitranscriptomic field lies in the further developments of novel technologies.
Competing Interests: Competing interestsW.S.S.G. owns shares in Oxford Nanopore Technologies. The remaining author hereby declares no conflict of interest relating to this manuscript.
(© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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