Merging Humans and Neuroprosthetics through Regenerative Peripheral Nerve Interfaces.
Autor: | Tian Y; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan., Vaskov AK; Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan., Adidharma W; Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan., Cederna PS; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.; Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan., Kemp SWP; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan.; Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan. |
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Jazyk: | angličtina |
Zdroj: | Seminars in plastic surgery [Semin Plast Surg] 2024 Feb 06; Vol. 38 (1), pp. 10-18. Date of Electronic Publication: 2024 Feb 06 (Print Publication: 2024). |
DOI: | 10.1055/s-0044-1779028 |
Abstrakt: | Limb amputations can be devastating and significantly affect an individual's independence, leading to functional and psychosocial challenges in nearly 2 million people in the United States alone. Over the past decade, robotic devices driven by neural signals such as neuroprostheses have shown great potential to restore the lost function of limbs, allowing amputees to regain movement and sensation. However, current neuroprosthetic interfaces have challenges in both signal quality and long-term stability. To overcome these limitations and work toward creating bionic limbs, the Neuromuscular Laboratory at University of Michigan Plastic Surgery has developed the Regenerative Peripheral Nerve Interface (RPNI). This surgical construct embeds a transected peripheral nerve into a free muscle graft, effectively amplifying small peripheral nerve signals to provide enhanced control signals for a neuroprosthetic limb. Furthermore, the RPNI has the potential to provide sensory feedback to the user and facilitate neuroprosthesis embodiment. This review focuses on the animal studies and clinical trials of the RPNI to recapitulate the promising trajectory toward neurobionics where the boundary between an artificial device and the human body becomes indistinct. This paper also sheds light on the prospects of the improvement and dissemination of the RPNI technology. Competing Interests: Conflict of Interest None declared. (Thieme. All rights reserved.) |
Databáze: | MEDLINE |
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