The relationship between oxidative stress markers and 1H-Magnetic resonance spectroscopy findings in obsessive compulsive disorder.

Autor: Subaşı Turgut F; Department of Child and Adolescent Psychiatry, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Bulut M; Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakır, Turkey. Electronic address: drmahmutbulut@yahoo.com., Hattapoğlu S; Department of Radiology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Güneş M; Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Cemal Kaya M; Department of Psychiatry, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Ekici F; Department of Radiology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Guli Çetinçakmak M; Department of Radiology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Kaplan İ; Department of Biochemistry, Faculty of Medicine, Dicle University, Diyarbakır, Turkey., Atmaca M; Department of Psychiatry, Faculty of Medicine, Fırat University, Elazığ, Turkey.
Jazyk: angličtina
Zdroj: Brain research [Brain Res] 2024 Jun 15; Vol. 1833, pp. 148852. Date of Electronic Publication: 2024 Mar 15.
DOI: 10.1016/j.brainres.2024.148852
Abstrakt: Introduction: The purpose of this study was to examine N-acetyl aspartate (NAA)/creatine (Cr) and glutamate, glutamine, and gamma-aminobutyric acid complex (Glx)/Cr levels in patients with obsessive compulsive disorder (OCD) and healthy controls' orbitofrontal cortex (OFC) and caudate nucleus (CN) by proton magnetic resonance spectroscopy (1H-MRS) method and to investigate their relationship with oxidative stress markers glutathione peroxidase (GPx) and superoxide dismutase (SOD).
Methods: This study included patients with OCD (n = 25) and healthy controls (n = 25) ranging in age from 18 to 65. We used the ELISA method to evaluate serum SOD and GPx levels. Levels of NAA/Cr and Glx/Cr in the orbitofrontal cortex and caudate nucleus were measured using the 1H-MRS method.
Results: Our study did not detect statistically significant differences in the orbitofrontal cortex Glx/Cr and NAA/Cr levels between the OCD patients and the control group. OCD patients exhibited a decrease in NAA/Cr levels, consistent with impaired neuronal integration, and an increase in Glx/Cr levels, consistent with hyperactivation, in the caudate nucleus compared to the control group. We observed a negative correlation between NAA/Cr levels in the caudate nucleus and the levels of SOD and GPx.
Conclusions: Our study is the first to assess CN and OFC together in OCD patients using 3 T MR, investigating the relationship between neurometabolite concentrations and oxidative stress parameters. The negative correlation we observed between NAA/Cr levels and SOD and GPx in the caudate nucleus suggests that increased oxidative stress in this brain region in OCD patients may contribute to impaired neuronal integration and functionality.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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