Major adverse events in youth-onset type 1 and type 2 diabetes: The SEARCH and TODAY studies.

Autor: Mottl AK; University of North Carolina Kidney Center, UNC School of Medicine, Chapel Hill, NC, United States. Electronic address: amy_mottl@med.unc.edu., Tryggestad JB; University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States., Isom S; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, United States., Gubitosi-Klug RA; Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine, Cleveland, OH, United States., Henkin L; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, United States., White NH; Washington University in St. Louis School of Medicine, St. Louis, MO, United States., D'Agostino R Jr; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, United States., Hughan KS; UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States., Dolan LM; University of Cincinnati College of Medicine, Cincinnati, OH, United States., Drews KL; The Biostatistics Center, George Washington University, Rockville, MD, United States.
Jazyk: angličtina
Zdroj: Diabetes research and clinical practice [Diabetes Res Clin Pract] 2024 Apr; Vol. 210, pp. 111606. Date of Electronic Publication: 2024 Mar 15.
DOI: 10.1016/j.diabres.2024.111606
Abstrakt: Aims: To determine contemporary incidence rates and risk factors for major adverse events in youth-onset T1D and T2D.
Methods: Participant interviews were conducted once during in-person visits from 2018 to 2019 in SEARCH (T1D: N = 564; T2D: N = 149) and semi-annually from 2014 to 2020 in TODAY (T2D: N = 495). Outcomes were adjudicated using harmonized, predetermined, standardized criteria.
Results: Incidence rates (events per 10,000 person-years) among T1D participants were: 10.9 ophthalmologic; 0 kidney; 11.1 nerve, 3.1 cardiac; 3.1 peripheral vascular; 1.6 cerebrovascular; and 15.6 gastrointestinal events. Among T2D participants, rates were: 40.0 ophthalmologic; 6.2 kidney; 21.2 nerve; 21.2 cardiac; 10.0 peripheral vascular; 5.0 cerebrovascular and 42.8 gastrointestinal events. Despite similar mean diabetes duration, complications were higher in youth with T2D than T1D: 2.5-fold higher for microvascular, 4.0-fold higher for macrovascular, and 2.7-fold higher for gastrointestinal disease. Univariate logistic regression analyses in T1D associated age at diagnosis, female sex, HbA1c and mean arterial pressure (MAP) with microvascular events. In youth-onset T2D, composite microvascular events associated positively with MAP and negatively with BMI, however composite macrovascular events associated solely with MAP.
Conclusions: In youth-onset diabetes, end-organ events were infrequent but did occur before 15 years diabetes duration. Rates were higher and had different risk factors in T2D versus T1D.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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