Efficacy of erythropoietin as a neuroprotective agent in CKD-associated cognitive dysfunction: A literature systematic review.

Autor: Barbieri M; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy. Electronic address: michelangela.barbieri@unicampania.it., Chiodini P; Medical Statistics Unit, University of Campania 'Luigi Vanvitelli', Caserta 81100, Italy., Di Gennaro P; Medical Statistics Unit, University of Campania 'Luigi Vanvitelli', Caserta 81100, Italy., Hafez G; Department of Pharmacology, Faculty of Pharmacy, Altinbas University, Istanbul, Turkey., Liabeuf S; Pharmacoepidemiology Unit, Department of Clinical Pharmacology, Amiens University Medical Center, Amiens, France; MP3CV Laboratory, EA7517, Jules Verne University of Picardie, Amiens, France., Malyszko J; Department of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, Warsaw, Poland., Mani LY; Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Mattace-Raso F; Department of Internal Medicine, Section of Geriatric Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands., Pepin M; Clinical Epidemiology, CESP, INSERM, UMR 1018, Paris Saclay University, Villejuif, France; Department of Geriatrics, Ambroise Paré University Medical Center, APHP, Boulogne-Billancourt, France., Perico N; Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy., Simeoni M; Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy., Zoccali C; Renal Research Institute, New York, USA; Institute of Biology and Molecular Biology (BIOGEM), Ariano Irpino, Italy; IPNET, Reggio Calabria, Italy., Tortorella G; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy., Capuano A; Section of Pharmacology 'L. Donatelli', Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology, Naples, Italy., Remuzzi G; Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy., Capasso G; Institute of Biology and Molecular Biology (BIOGEM), Ariano Irpino, Italy., Paolisso G; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy; UniCamillus, International Medical University, Rome, Italy.
Jazyk: angličtina
Zdroj: Pharmacological research [Pharmacol Res] 2024 May; Vol. 203, pp. 107146. Date of Electronic Publication: 2024 Mar 16.
DOI: 10.1016/j.phrs.2024.107146
Abstrakt: Patients with chronic kidney disease (CKD) often experience mild cognitive impairment and other neurocognitive disorders. Studies have shown that erythropoietin (EPO) and its receptor have neuroprotective effects in cell and animal models of nervous system disorders. Recombinant human EPO (rHuEPO), commonly used to treat anemia in CKD patients, could be a neuroprotective agent. In this systematic review, we aimed to assess the published studies investigating the cognitive benefits of rHuEPO treatment in individuals with reduced kidney function. We comprehensively searched Pubmed, Cochrane Library, Scopus, and Web of Science databases from 1990 to 2023. After selection, 24 studies were analyzed, considering study design, sample size, participant characteristics, intervention, and main findings. The collective results of these studies in CKD patients indicated that rHuEPO enhances brain function, improves performance on neuropsychological tests, and positively affects electroencephalography measurements. These findings suggest that rHuEPO could be a promising neuroprotective agent for managing CKD-related cognitive impairment.
Competing Interests: Declaration of Competing Interest All authors have no potential conflicts of interest to be disclosed or relevant financial interest in this manuscript. Declaration of interest None No competing interest
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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