AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation.

Autor: Cicek B; Department of Physiology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan 24100, Turkey., Hacimuftuoglu A; Department of Medical Pharmacology, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey. Electronic address: ahmeth@atauni.edu.tr., Yeni Y; Department of Medical Pharmacology, Faculty of Medicine, Malatya Turgut Ozal University, Malatya 44210, Turkey. Electronic address: yesimyeni.75@outlook.com.tr., Kuzucu M; Department of Biology, Faculty of Arts and Sciences, Erzincan Binali Yildirim University, Erzincan 24100, Turkey. Electronic address: mkuzucu@erzincan.edu.tr., Genc S; Bilecik Şeyh Edebali University, Faculty of Medicine, Department of Medical Pharmacology, Bilecik 11230, Turkey., Cetin A; Department of Biology, Faculty of Arts and Sciences, Erzincan Binali Yildirim University, Erzincan 24100, Turkey., Yavuz E; Department of Medical Services and Technicians, Çayirli Vocational School, Erzincan Binali Yildirim University, Erzincan, Turkey. Electronic address: emre.yavuz@erzincan.edu.tr., Danısman B; Department of Biophysics, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey. Electronic address: betul.danisman@atauni.edu.tr., Levent A; Department of Radiology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan 24100, Turkey. Electronic address: alevent@erzincan.edu.tr., Ozdokur KV; Sciences Application and Research Center, Erzincan Binali Yildirim University, Erzincan 24100, Turkey. Electronic address: vozdokur@erzincan.edu.tr., Kantarcı M; Department of Radiology, Faculty of Medicine, Ataturk University, Erzurum 25240, Turkey., Docea AO; Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania. Electronic address: ancadocea@gmail.com., Siokas V; Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa 41100, Greece., Tsarouhas K; Department of Cardiology, University Hospital of Larissa, Larissa 41100, Greece., Coleman MD; College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK. Electronic address: m.d.coleman@aston.ac.uk., Tsatsakis A; Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion 71003, Greece. Electronic address: tsatsaka@uoc.gr., Taghizadehghalehjoughi A; Bilecik Şeyh Edebali University, Faculty of Medicine, Department of Medical Pharmacology, Bilecik 11230, Turkey. Electronic address: ali.tgzd@bilecik.edu.tr.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2024 Apr; Vol. 107, pp. 104417. Date of Electronic Publication: 2024 Mar 15.
DOI: 10.1016/j.etap.2024.104417
Abstrakt: The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO 2 ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: