Diagnostic validity and reliability of BT-RADS in the management of recurrent high-grade glioma.

Autor: Ebaid NY; Department of Radiology, Faculty of medicine, Zagazig University, Zagazig, Egypt; Negida academy LLC, Arlington, MA, USA., Ahmed RN; Department of Surgery, College of medicine, Ninevah University, Mosul, Iraq., Assy MM; Department of Radiology, Faculty of medicine, Zagazig University, Zagazig, Egypt., Amin MI; Department of Radiology, Faculty of medicine, Zagazig University, Zagazig, Egypt., Alaa Eldin AM; Department of Radiology, Faculty of medicine, Zagazig University, Zagazig, Egypt., Alsowey AM; Department of Radiology, Faculty of medicine, Zagazig University, Zagazig, Egypt., Abdelhay RM; Department of Radiology, Faculty of medicine, Zagazig University, Zagazig, Egypt.
Jazyk: angličtina
Zdroj: Journal of neuroradiology = Journal de neuroradiologie [J Neuroradiol] 2024 Jun; Vol. 51 (4), pp. 101190. Date of Electronic Publication: 2024 Mar 14.
DOI: 10.1016/j.neurad.2024.03.001
Abstrakt: Background and Purpose: BT-RADS is a new framework system for reporting the treatment response of brain tumors. The aim of the study was to assess the diagnostic performance and reliability of the BT-RADS in predicting the recurrence of high-grade glioma (HGG).
Materials and Methods: This prospective single-center study recruited 81 cases with previously operated and pathologically proven HGG. The patients underwent baseline and follow-up contrast-enhanced MRI (CE-MRI). Two neuro-radiologists with ten years-experience in neuroimaging independently analyzed and interpreted the MRI images and assigned a BT-RADS category for each case. To assess the diagnostic accuracy of the BT-RADS for detecting recurrent HGG, the reference standard was the histopathology for BT-RADS categories 3 and 4, while neurological clinical examination and clinical follow up were used as a reference for BT-RADS categories 1 and 2. The inter-reader agreement was assessed using the Cohen's Kappa test.
Results: The study included 81 cases of HGG, of which 42 were recurrent and 39 were non-recurrent HGG cases based on the reference test. BT-RADS 3B was the best cutoff for predicting recurrent HGG with a sensitivity of 90.5 % to 92.9 %, specificity of 76.9 % to 84.6 %, and accuracy of 83.9 % to 88.9 %, based on both readers. The BT-RADS showed a substantial inter-reader agreement with a K of 0.710 (P = 0.001).
Conclusions: The BT-RADS is a valid and reliable framework for predicting recurrent HGG. Moreover, BT-RADS can help neuro-oncologists make clinical decisions that can potentially improve the patient's outcome.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial or personal relationships that could be viewed as influencing the work reported in this paper.
(Copyright © 2024 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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