Physical Activity and Sedentary Behavior as Treatable Traits for Clinical Control in Moderate-to-Severe Asthma.

Autor:	de Lima FF; Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil., Dos Santos JMB; Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil., Lunardi AC; Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil., de Oliveira JM; Biological and Health Sciences Center, UNOPAR Pitágoras University, Londrina, Brazil; Laboratory of Research in Pulmonary Physiotherapy, State University of Londrina (UEL), Londrina, Brazil., Freitas PD; Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil., Kim FS; Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil., Agondi RC; Clinical Immunology and Allergy Division, School of Medicine, University of São Paulo, São Paulo, Brazil., Carvalho-Pinto RM; Pulmonary Division, Heart Institute (InCor), School of Medicine, University of São Paulo, São Paulo, Brazil., Furlanetto KC; Biological and Health Sciences Center, UNOPAR Pitágoras University, Londrina, Brazil; Laboratory of Research in Pulmonary Physiotherapy, State University of Londrina (UEL), Londrina, Brazil., Carvalho CRF; Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, Brazil. Electronic address: cscarval@usp.br.
Jazyk:	angličtina
Zdroj:	The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2024 Aug; Vol. 12 (8), pp. 2047-2055. Date of Electronic Publication: 2024 Mar 15.
DOI:	10.1016/j.jaip.2024.03.012
Abstrakt:	Background: Physical activity and sedentary behavior are treatable traits that may impact asthma control in distinct manners, but this impact remains poorly understood. Objective: To evaluate the influence of physical activity and sedentary behavior on clinical control in adults with moderate-to-severe asthma. Methods: This cross-sectional, multicentric study included 426 individuals with moderate-to-severe asthma. Assessments included physical activity and sedentary time (actigraphy), clinical asthma control (Asthma Control Questionnaire [ACQ]), quality of life (Asthma Quality of Life Questionnaire), anxiety and depression symptoms (Hospital Anxiety and Depression Scale), anthropometric data, and lung function. Participants were grouped according to physical activity levels and sedentary behavior. Results: Participants who walked ≥7500 steps/day presented better ACQ scores than those who walked <7500 steps/day (P < .05), independent of sedentary status. The percentage of patients with controlled asthma was higher in the active/sedentary (43.9%) and active/nonsedentary (43.8%) groups than in the inactive/sedentary (25.4%) and inactive/nonsedentary (23.9%) groups (P < .02). The likelihood of having uncontrolled asthma according to the treatable traits of physical inactivity (odds ratio [95% confidence interval]: 2.36 [1.55-3.59]), higher anxiety (2.26 [1.49-3.42]), and depression symptoms (1.95 [1.28-2.95]) was significant (P ≤ .002). Obesity and sedentary time were not associated with asthma control. Conclusions: Our results show that ≥7500 steps/day is associated with better asthma control independent of sedentary time in adults with moderate-to-severe asthma. Physical inactivity, anxiety, and depression symptoms are associated with higher odds of uncontrolled asthma. These results suggest that interventions should mainly focus on increasing physical activity rather than reducing sedentary time. (Copyright © 2024 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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