Deciphering the role of MicroRNAs in diabetic nephropathy: Regulatory mechanisms and molecular insights.

Autor: Abdelmaksoud NM; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Al-Noshokaty TM; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt. Electronic address: Tohada.mohamed@hu.edu.eg., Abdelhamid R; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abdellatif N; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Mansour A; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Mohamed R; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Mohamed AH; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Khalil NAE; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abdelhamid SS; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Mohsen A; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Abdelaal H; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Tawfik A; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt., Elshaer SS; Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr city, Cairo 11754, Egypt. Electronic address: sherien.saied@hu.edu.eg.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Apr; Vol. 256, pp. 155237. Date of Electronic Publication: 2024 Mar 04.
DOI: 10.1016/j.prp.2024.155237
Abstrakt: A serious consequence of diabetes mellitus, diabetic nephropathy (DN) which causes gradual damage to the kidneys. Dietary changes, blood pressure control, glucose control, and hyperlipidemia are all important components of DN management. New research, however, points to microRNAs (miRNAs) as having a pivotal role in DN pathogenesis. Miniature non-coding RNA molecules such as miRNAs control gene expression and impact several biological processes. The canonical and non-canonical routes of miRNA biogenesis are discussed in this article. In addition, several important signaling pathways are examined in the study of miRNA regulation in DN. A deeper knowledge of these regulatory mechanisms would allow for a better understanding of the molecular basis of DN and the development of innovative therapeutic strategies. Finally, miRNAs show tremendous potential as DN diagnostic biomarkers and treatment targets, opening up promising avenues for further study and potential clinical use.
Competing Interests: Declaration of Competing Interest The authors report no declaration of interest.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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