Dynamics of Changes in the cAMP/cGMP Concentration Ratio in the Thymus and Spleen of Laboratory Mice during Vaccination against Plague and Tularemia against the Background of Immunomodulation.

Autor: Dubrovina VI; Irkutsk Antiplague Research Institute of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia. dubrovina-valya@mail.ru., Yur'eva OV; Irkutsk Antiplague Research Institute of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Pyatidesyatnikova AB; Irkutsk Antiplague Research Institute of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Starovoitova TP; Irkutsk Antiplague Research Institute of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia., Balakhonov SV; Irkutsk Antiplague Research Institute of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 Feb; Vol. 176 (4), pp. 472-476. Date of Electronic Publication: 2024 Mar 16.
DOI: 10.1007/s10517-024-06049-4
Abstrakt: Vaccine strains Yersinia pestis EV NIIEG at a dose of 10 3 CFU and Francisella tularensis 15 NIIEG at a dose of 10 2 CFU induced changes in the concentration of cyclic nucleotides in the thymus and spleen of white mice. Antigen-induced changes in the cAMP/cGMP ratio in immunocompetent organs had a phase or oscillatory character, which seems to be related to the regulation of postvaccination immunoreactivity in the body. Synthetic organoselenium compound 974zh stimulated an increase in the amplitude of cAMP/cGMP oscillations, indicating its stimulating effect on the immunogenic properties of vaccine strains at doses an order of magnitude below the standard doses.
(© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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