Transcriptomic contributions to a modern cytoarchitectonic parcellation of the human cerebral cortex.

Autor: King L; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA. leana.king@berkeley.edu.; Department of Neuroscience, University of California Berkeley, Berkeley, CA, 94720, USA. leana.king@berkeley.edu., Weiner KS; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.; Department of Neuroscience, University of California Berkeley, Berkeley, CA, 94720, USA.; Department of Psychology, University of California Berkeley, Berkeley, CA, 94720, USA.
Jazyk: angličtina
Zdroj: Brain structure & function [Brain Struct Funct] 2024 May; Vol. 229 (4), pp. 919-936. Date of Electronic Publication: 2024 Mar 16.
DOI: 10.1007/s00429-023-02754-4
Abstrakt: Transcriptomic contributions to the anatomical, functional, and network layout of the human cerebral cortex (HCC) have become a major interest in cognitive and systems neuroscience. Here, we tested if transcriptomic differences support a modern, algorithmic cytoarchitectonic parcellation of HCC. Using a data-driven approach, we identified a sparse subset of genes that differentially contributed to the cytoarchitectonic parcellation of HCC. A combined metric of cortical thickness and myelination (CT/M ratio), as well as cell density, correlated with gene expression. Enrichment analyses showed that genes specific to the cytoarchitectonic parcellation of the HCC were related to molecular functions such as transmembrane transport and ion channel activity. Together, the relationship between transcriptomics and cytoarchitecture bridges the gap among (i) gradients at the macro-scale (including thickness and myelination), (ii) areas at the meso-scale, and (iii) cell density at the microscale, as well as supports the recently proposed cortical spectrum theory and structural model.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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