A biological characterization of patients with postmenopausal Parkinson's disease.

Autor: Bovenzi R; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Schirinzi T; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy. t.schirinzi@yahoo.com., Conti M; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Sancesario GM; IRCCS Fondazione Santa Lucia, European Centre for Brain Research, Rome, Italy., Zenuni H; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Simonetta C; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Bissacco J; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Mascioli D; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Pieri M; Department of Experimental Medicine, University of Rome 'Tor Vergata', Rome, Italy.; Department of Clinical Biochemistry, Tor Vergata University Hospital, Rome, Italy., Cerroni R; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Stefani A; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy.; UOSD Parkinson Centre, Tor Vergata University Hospital, Rome, Italy., Mercuri NB; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Pierantozzi M; Unit of Neurology, Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2024 Jun; Vol. 271 (6), pp. 3610-3615. Date of Electronic Publication: 2024 Mar 16.
DOI: 10.1007/s00415-024-12258-8
Abstrakt: Menopause increases the risk for Parkinson's disease (PD), although the underlying biological mechanisms have not been established in patients. Here, we aimed to understand the basis of menopause-related vulnerability to PD. Main motor and non-motor scores, blood levels of estradiol, testosterone, follicle-stimulating hormone, and luteinizing hormone, CSF levels of total α-synuclein, amyloid-β-42, amyloid-β-40, total tau, and phosphorylated-181-tau were examined in 45 women with postmenopausal-onset PD and 40 age-matched controls. PD patients had higher testosterone and lower estradiol levels than controls, and the residual estradiol production was associated with milder motor disturbances and lower dopaminergic requirements. In PD but not in controls, follicle-stimulating hormone levels correlated with worse cognitive scores and CSF markers of amyloidopathy and neuronal loss. In conclusion, menopause-related hormonal changes might differentially contribute to clinical-pathological trajectories of PD, accounting for the peculiar vulnerability to the disease.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
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