The A1/A2 β-casein genotype of cows, but not their horn status, influences peptide generation during simulated digestion of milk.

Autor:	Reiche AM; Ruminant Nutrition and Emissions, Agroscope, 1725 Posieux, Switzerland. Electronic address: anna-maria.reiche@agroscope.admin.ch., Martín-Hernández MC; Method Development and Analytics/Biochemistry of Milk and Microorganisms, Agroscope, 3097 Liebefeld, Switzerland., Spengler Neff A; Department of Livestock Sciences, Research Institute of Organic Agriculture (FiBL), Ackerstrasse 113, CH-5070 Frick, Switzerland., Bapst B; Qualitas AG, 6300 Zug, Switzerland., Fleuti C; Method Development and Analytics/Biochemistry of Milk and Microorganisms, Agroscope, 3097 Liebefeld, Switzerland., Dohme-Meier F; Ruminant Nutrition and Emissions, Agroscope, 1725 Posieux, Switzerland., Hess HD; Ruminant Nutrition and Emissions, Agroscope, 1725 Posieux, Switzerland., Egger L; Method Development and Analytics/Biochemistry of Milk and Microorganisms, Agroscope, 3097 Liebefeld, Switzerland., Portmann R; Method Development and Analytics/Biochemistry of Milk and Microorganisms, Agroscope, 3097 Liebefeld, Switzerland.
Jazyk:	angličtina
Zdroj:	Journal of dairy science [J Dairy Sci] 2024 Sep; Vol. 107 (9), pp. 6425-6436. Date of Electronic Publication: 2024 Mar 14.
DOI:	10.3168/jds.2024-24403
Abstrakt:	The effect of the horn status of cows on their milk composition and quality is a controversial research topic. In this study, 128 milk samples from 64 horned and 64 disbudded Brown Swiss and Original Braunvieh cows were collected from alpine farms where both horned and disbudded cows were grazing on mountain pastures. The samples were analyzed for their detailed composition and protein digestion in a simulated in vitro digestion (INFOGEST). To exclude probable influences on digestion, the β-CN genotype with its variants A1 and A2 was also included in the study. The effects of horn status and β-CN genotype were investigated in linear mixed models, which included additional influencing random factors such as Original Braunvieh blood proportion, stage of lactation, and farm. Horn status did not have any effect on milk composition or digestion. In contrast, milk from A1A1 cows showed a different protein digestion than milk of A1A2 and A2A2 cows in the gastric phase, including smaller amounts of β-casomorphin(BCM)21-associated peptides and larger amounts of BCM11-associated peptides. Abundances of BCM7 did not differ between β-CN genotypes. At the end of the intestinal phase, the digested milk of A1A1 and A2A2 β-CN genotypes did not differ. (The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association®. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).)
Databáze:	MEDLINE
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