The pelvic organs receive no parasympathetic innervation.

Autor:	Sivori M; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France., Dempsey B; Faculty of Medicine, Health & Human Sciences, Macquarie University, Macquarie Park, Sydney, Australia., Chettouh Z; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France., Boismoreau F; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France., Ayerdi M; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France., Eymael A; Faculty of Medicine, Health & Human Sciences, Macquarie University, Macquarie Park, Sydney, Australia., Baulande S; Institut Curie, PSL University, ICGex Next-Generation Sequencing Platform, Paris, France., Lameiras S; Institut Curie, PSL University, ICGex Next-Generation Sequencing Platform, Paris, France., Coulpier F; GenomiqueENS, Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, Paris, France.; Inserm U955, Mondor Institute for Biomedical Research (IMRB), Creteil, France., Delattre O; Institut Curie, Inserm U830, PSL Research University, Diversity and Plasticity of Childhood Tumors Lab, Paris, France., Rohrer H; Institute of Clinical Neuroanatomy, Dr. Senckenberg Anatomy, Neuroscience Center, Goethe University, Frankfurt am Main, Germany., Mirabeau O; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France., Brunet JF; Institut de Biologie de l'ENS (IBENS), Inserm, CNRS, École normale supérieure, PSL Research University, Paris, France.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2024 Mar 15; Vol. 12. Date of Electronic Publication: 2024 Mar 15.
DOI:	10.7554/eLife.91576
Abstrakt:	The pelvic organs (bladder, rectum, and sex organs) have been represented for a century as receiving autonomic innervation from two pathways - lumbar sympathetic and sacral parasympathetic - by way of a shared relay, the pelvic ganglion, conceived as an assemblage of sympathetic and parasympathetic neurons. Using single-cell RNA sequencing, we find that the mouse pelvic ganglion is made of four classes of neurons, distinct from both sympathetic and parasympathetic ones, albeit with a kinship to the former, but not the latter, through a complex genetic signature. We also show that spinal lumbar preganglionic neurons synapse in the pelvic ganglion onto equal numbers of noradrenergic and cholinergic cells, both of which therefore serve as sympathetic relays. Thus, the pelvic viscera receive no innervation from parasympathetic or typical sympathetic neurons, but instead from a divergent tail end of the sympathetic chains, in charge of its idiosyncratic functions. Competing Interests: MS, BD, ZC, FB, MA, AE, SB, SL, FC, OD, HR, OM, JB No competing interests declared (© 2023, Sivori, Dempsey et al.)
Databáze:	MEDLINE
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