Anti-SAE dermatomyositis: clinical and histologic characteristics from a monocentric Italian cohort.

Autor:	Fornaro M; Unit of Rheumatology, Department of Precision and Regenerative Medicine, Area Jonica (DiMePRe-J), University of Bari, Italy., Coladonato L; Unit of Rheumatology, Department of Precision and Regenerative Medicine, Area Jonica (DiMePRe-J), University of Bari, Italy., Giannini M; Physiologie et Explorations Fonctionnelles Musculaires, University Hospital of Strasbourg; UR3072 Mitochondrie, Stress Oxydant et Protection Musculaire, Centre de Recherche en Biomédecine, University of Strasbourg; and Centre de Référence des Maladies Auto-immunes Systémiques Rares, University Hospital of Strasbourg, France., Napoletano A; Unit of Rheumatology, Department of Precision and Regenerative Medicine, Area Jonica (DiMePRe-J), University of Bari, Italy., Girolamo F; Unit of Human Anatomy and Histology, Department of Translational Biomedicine and Neuroscience 'DiBraiN', University of Bari, Italy., D'Abbicco D; Institute of General Surgery 'G Marinaccio', Department of Precision and Regenerative Medicine, Area Jonica (DiMePRe-J), University of Bari, Italy., Ruggieri M; Neurochemistry Lab, Department of Translational Biomedicine and Neuroscience 'DiBraiN', University of Bari, Italy., Sabella DVA; Unit of Rheumatology, Department of Precision and Regenerative Medicine, Area Jonica (DiMePRe-J), University of Bari, Italy., Iannone F; Unit of Rheumatology, Department of Precision and Regenerative Medicine, Area Jonica (DiMePRe-J), University of Bari, Italy. florenzo.iannone@uniba.it.
Jazyk:	angličtina
Zdroj:	Clinical and experimental rheumatology [Clin Exp Rheumatol] 2024 Feb; Vol. 42 (2), pp. 295-301. Date of Electronic Publication: 2024 Mar 14.
DOI:	10.55563/clinexprheumatol/110r0p
Abstrakt:	Objectives: Multiple myositis-specific antibodies have been identified, each associated with different clinical subsets of dermatomyositis (DM). Anti-SAE associated DM is considered the least studied subset. Our study aimed to evaluate the clinical and histological characteristics of DM patients with anti-SAE antibodies. As reference, patients with anti-Mi2 antibodies associated DM, representing a well-characterised subset, were analysed. Methods: We recorded data from our DM cohort in the INflammatory MYositis REgistry (INMYRE). Patients were divided into two groups: those positive for anti-SAE and those positive for anti-Mi2 antibodies. Clinical characteristics, including skin, muscle, and extra-muscular involvements, were recorded. Available muscle biopsies were compared between the two groups. Results: Of 92 DM patients, 10 (10.9%) were positive for anti-SAE and 17 (18.5%) for anti-Mi2. Anti-SAE positive DM patients showed classic DM findings but were characterised by a higher prevalence of skin itching (60% vs. 11.8%, p<0.01), shawl sign (40% vs. 5.9%, p<0.05) and lung involvement (30% vs. 0%, p<0.05) compared to anti-Mi2 positive patients. Furthermore, anti-SAE positive DM patients showed lower creatine kinase levels than those with anti-Mi2 (median [IQR]: 101 [58-647] vs. 1984 [974-3717], p<0.05) and a lower percentage of muscle fibre degeneration and necrosis (1.5%±1.7 vs. 5.9%±3.2, p<0.05) in muscle biopsies. No other differences were observed. Conclusions: Anti-SAE DM represents a disease subset characterised by classic cutaneous involvement often associated with itching, less severe muscle involvement, but potential pulmonary involvement that should always be investigated in these patients.
Databáze:	MEDLINE
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