Autor: |
Fayad E; Department of Biotechnology, College of Sciences, Taif University, PO Box 11099, Taif, 21944, Saudi Arabia., Binjawhar DN; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, PO Box 84428, Riyadh, 11671, Saudi Arabia., Ageeli AA; Department of Physical Sciences, Chemistry Division, College of Science, Jazan University, Jazan, PO Box 114, Jazan 45142, Kingdom of Saudi Arabia., Alshaya DS; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, PO Box 84428, Riyadh, 11671, Saudi Arabia., Elsaid FG; Department of Biology, College of Science, King Khalid University, PO Box 960, Asir, Abha, 61421, Saudi Arabia., Mahmoud AY; Department of Chemistry, Faculty of Science, Port Said University, Port Said, 42526, Egypt., Radwan EM; Department of Chemistry, Faculty of Science, Port Said University, Port Said, 42526, Egypt., Elian Sophy MA; Department of Chemistry, Faculty of Science, Arish University, Arish, 45511, Egypt., Mahdy AR; Department of Chemistry, Faculty of Science, Port Said University, Port Said, 42526, Egypt. |
Abstrakt: |
Background: 4-Methylacetophenone is used in the preparation of starting materials, 4-methylphenacyle bromide ( 2 ) and 4-methylacetophenone thiosemicarbazole ( 3 ). Results: Several novel 2,4-disubstituted-1,3-thiazole analogues were obtained via the treatment of starting materials with 4-methylphenacyl bromide, acetyl chloride, aromatic aldehydes and bromination providing thiazole derivatives 5-8 respectively. Conclusion: Compounds 5-8 were investigated for their cytotoxic activity on MCF-7 and normal breast cells. Active compounds were found and in contrast to staurosporine, compound 8 displayed the most potent cytotoxic action that showed a strong inhibitory effect (aromatase) and (protein tyrosine kinase) enzymes, proving that the novel thiazole derivatives promoted the effective anticancer drug candidates. |