The role of microbiota on rheumatoid arthritis onset.

Autor: Juárez-Chairez MF; Laboratorios de Inmunología y Biología Molecular, Unidad Académica de Ciencias Biológicas de la Universidad Autónoma de Zacatecas, Zacatecas, Mexico., Cid-Gallegos MS; Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Ciudad de Mexico, Mexico., Jiménez-Martínez C; Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, Ciudad de Mexico, Mexico., Prieto-Contreras LF; Laboratorio de Microbiología, Unidad Académica de Ciencias Químicas de la Universidad Autónoma de Zacatecas, Zacatecas, Mexico., Bollain-Y-Goytia de-la-Rosa JJ; Laboratorios de Inmunología y Biología Molecular, Unidad Académica de Ciencias Biológicas de la Universidad Autónoma de Zacatecas, Zacatecas, Mexico.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2024 Mar; Vol. 27 (3), pp. e15122.
DOI: 10.1111/1756-185X.15122
Abstrakt: Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and pain, which can lead to the loss of normal joint function. Although the exact cause of the disease is not yet fully understood, both environmental factors and genetics may play a role in its development. Moreover, research suggests microbiota contributes to the onset and progression of RA. People with RA show higher quantities of bacteria such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Prevotella copri, Proteus mirabilis, and Lactobacillus salivarius compared to healthy individuals. Conversely, studies propose that Lactobacillus casei, a probiotic bacterium with immunomodulatory properties, has beneficial effects for RA in murine and human models. Therefore, this work reviews the potential role of the gut microbiota in the development of RA and explores the feasibility of using probiotic bacteria as a supplementary treatment for this disease.
(© 2024 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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