Case report: Death caused by multi-organ metastatic calcifications as a result of intramuscular injections with paraffin oil.

Autor:	Jakobsen SR; Department of Forensic Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N 8200, Denmark., Diaz-delCastillo M; Department of Forensic Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N 8200, Denmark., Jensen MB; Department of Endocrinology, Copenhagen University Hospital, Herlev-Gentofte Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Andersen TL; Department of Forensic Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N 8200, Denmark., Eldrup E; Department of Endocrinology, Copenhagen University Hospital, Herlev-Gentofte Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Nielsen TS; Department of Forensic Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, Aarhus N 8200, Denmark.
Jazyk:	angličtina
Zdroj:	Bone reports [Bone Rep] 2024 Mar 05; Vol. 20, pp. 101749. Date of Electronic Publication: 2024 Mar 05 (Print Publication: 2024).
DOI:	10.1016/j.bonr.2024.101749
Abstrakt:	In this forensic case report, we present autopsy findings from a young male in his thirties who had been self-injecting paraffin oil into his upper extremities 8 years prior to death. The injections induced an inflammatory response, leading to granuloma formation. This, in turn, resulted in severe hypercalcemia. The external autopsy examination revealed gross macroscopic ulcerations and enlargement of upper extremities, while calcifications of ligaments, heart, kidneys and dura mater was revealed on postmortem CT-scans. Histopathological examination showed extensive multiorgan metastatic calcifications in several tissues including the lungs, heart and kidney. Cause of death was estimated to be the extensive calcific deposits in the heart likely resulting in cardiac arrest. To our knowledge this is the first case reporting findings from an autopsy in which the cause of death was linked to cosmetic oil injections. Competing Interests: None to declare. No external funding was received. (© 2024 The Authors. Published by Elsevier Inc.)
Databáze:	MEDLINE
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