Advances in biomarkers for vasospasm - Towards a future blood-based diagnostic test.

Autor:	Mittal AM; University of Pittsburgh Medical Center, Department of Neurosurgery, Pittsburgh, PA, USA., Nowicki KW; Yale University, Department of Neurosurgery, New Haven, CT, USA., Mantena R; University of Pittsburgh Medical Center, Department of Neurosurgery, Pittsburgh, PA, USA., Cao C; University of Pittsburgh Medical Center, Department of Neurosurgery, Pittsburgh, PA, USA., Rochlin EK; Loyola University Stritch School of Medicine, Maywood, IL, USA., Dembinski R; University of Pittsburgh Medical Center, Department of Neurosurgery, Pittsburgh, PA, USA., Lang MJ; University of Pittsburgh Medical Center, Department of Neurosurgery, Pittsburgh, PA, USA., Gross BA; University of Pittsburgh Medical Center, Department of Neurosurgery, Pittsburgh, PA, USA., Friedlander RM; University of Pittsburgh Medical Center, Department of Neurosurgery, Pittsburgh, PA, USA.
Jazyk:	angličtina
Zdroj:	World neurosurgery: X [World Neurosurg X] 2024 Mar 03; Vol. 22, pp. 100343. Date of Electronic Publication: 2024 Mar 03 (Print Publication: 2024).
DOI:	10.1016/j.wnsx.2024.100343
Abstrakt:	Objective: Cerebral vasospasm and the resultant delayed cerebral infarction is a significant source of mortality following aneurysmal SAH. Vasospasm is currently detected using invasive or expensive imaging at regular intervals in patients following SAH, thus posing a risk of complications following the procedure and financial burden on these patients. Currently, there is no blood-based test to detect vasospasm. Methods: PubMed, Web of Science, and Embase databases were systematically searched to retrieve studies related to cerebral vasospasm, aneurysm rupture, and biomarkers. The study search dated from 1997 to 2022. Data from eligible studies was extracted and then summarized. Results: Out of the 632 citations screened, only 217 abstracts were selected for further review. Out of those, only 59 full text articles met eligibility and another 13 were excluded. Conclusions: We summarize the current literature on the mechanism of cerebral vasospasm and delayed cerebral ischemia, specifically studies relating to inflammation, and provide a rationale and commentary on a hypothetical future bloodbased test to detect vasospasm. Efforts should be focused on clinical-translational approaches to create such a test to improve treatment timing and prediction of vasospasm to reduce the incidence of delayed cerebral infarction. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors. Published by Elsevier Inc.)
Databáze:	MEDLINE
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