Optical Coherence Tomography Angiography Changes in Patients Diagnosed With Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.

Autor:	Sideri AM; First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC., Mitsopoulou D; First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC., Kandarakis SA; First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC., Katsimpris A; Ophthalmology, Princess Alexandra Eye Pavilion, Edinburgh, GBR., Kanakis M; Ophthalmology, University Eye Clinic, Rion University Hospital, University of Patras, Patras, GRC., Karamaounas A; First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC., Brouzas D; Ophthalmology, National and Kapodistrian University of Athens, Athens, GRC., Petrou P; First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC., Papakonstantinou E; First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC., Droutsas K; First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC., Giannopoulos G; Third Department of Cardiology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GRC., Georgalas I; First Department of Ophthalmology, G. Gennimatas Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Feb 13; Vol. 16 (2), pp. e54121. Date of Electronic Publication: 2024 Feb 13 (Print Publication: 2024).
DOI:	10.7759/cureus.54121
Abstrakt:	We conducted a systematic review and meta-analysis to assess the association between optical coherence tomography angiography (OCTA) parameters and acute coronary syndrome (ACS). Two independent reviewers searched the electronic databases (MEDLINE (Medical Literature Analysis and Retrieval System Online), Scopus, Embase (Excerpta Medica Database), Cochrane Library, ClinicalTrials.gov, and World Health Organization International Clinical Trials Registry Platform) from inception until April 2023. According to the inclusion criteria of this review, eligible were observational studies, randomized control trials, and registry/database studies that included the eyes of adult ACS patients and assessed OCTA parameters within the macula. The pooled standardized mean differences (SMD) between patients diagnosed with ACS and healthy controls with a confidence interval (CI) of 95% were calculated using the Hartung-Knapp-Sidik-Jonkman random-effects method. The heterogeneity was assessed by I 2 and the Cochran Q and a random effects model was applied. Seven studies were eligible and included in our systematic review (n = 898), of which three were included in the meta-analysis (n = 341). The pooled SMD in the superficial vascular plexus (SVP), deep vascular plexus (DVP), and foveal avascular zone (FAZ) were -0.46 (95% CI: -0.94 to 0.01, p = 0.05, I 2 = 0%, three studies), -0.10 (95% CI: -3.20 to 3.00, p = 0.75, I 2 = 67%, two studies), and 0.43 (95% CI: -1.22 to 2.09, p = 0.38, I 2 = 92%, three studies), respectively. Our findings suggest that there are no differences in OCTA metrics between ACS patients and healthy individuals. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Sideri et al.)
Databáze:	MEDLINE
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