Implementation of an extracorporeal resuscitation (ECPR) program for out-of-hospital cardiac arrest in Stockholm, Sweden: Feasibility, safety, and outcome.

Autor:	Frykler Abazi L; Department of Clinical Science and Education, Södersjukhuset, Center for Resuscitation Science, Karolinska Institutet, Sweden., Liliequist A; Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden., Böhm F; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden., Hedberg M; Capio Rapid Response Cars and Perioperative Medicine & Intensive Care, Karolinska University Hospital and Department of Physiology and Pharmacology, Karolinska Institutet, Sweden., Simonsson M; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden., Bäckman A; Department of Clinical Science and Education, Södersjukhuset, Center for Resuscitation Science, Karolinska Institutet, Sweden., Ax M; Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden., Braunschweig F; Department of Cardiology, Heart and Vascular Center, Karolinska University Hospital, Stockholm, Sweden., Mellbin L; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden., Linder R; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden., Svensson L; Department of Clinical Science and Education, Södersjukhuset, Center for Resuscitation Science, Karolinska Institutet, Sweden., Jurga J; Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden., Nordberg P; Department of Clinical Science and Education, Södersjukhuset, Center for Resuscitation Science, Karolinska Institutet, Sweden., Ringh M; Department of Clinical Science and Education, Södersjukhuset, Center for Resuscitation Science, Karolinska Institutet, Sweden., Forsberg S; Department of Clinical Science and Education, Södersjukhuset, Center for Resuscitation Science, Karolinska Institutet, Sweden., Hollenberg J; Department of Clinical Science and Education, Södersjukhuset, Center for Resuscitation Science, Karolinska Institutet, Sweden.
Jazyk:	angličtina
Zdroj:	Resuscitation plus [Resusc Plus] 2024 Mar 07; Vol. 18, pp. 100596. Date of Electronic Publication: 2024 Mar 07 (Print Publication: 2024).
DOI:	10.1016/j.resplu.2024.100596
Abstrakt:	Background: The aim of this study was to evaluate the implementation of a novel extra corporeal cardiopulmonary (ECPR) program in the greater Stockholm area with focus on feasibility, safety aspects and clinical outcomes. Methods: Prospective observational study of ECPR program including patients with OHCA from January 2020 to December 2022, fulfilling ECPR criteria: age 18-65 years, initial shockable rhythm or pulseless electrical activity, witnessed arrest, bystander cardiopulmonary resuscitation and refractory arrest after three cycles of advance cardiac life support. The predefined time threshold from collapse to extracorporeal membrane oxygenation (ECMO) initiation was set at 60 min. Results: We included 95 patients. Of these, 22/95 (23%) had return of spontaneous circulation before ECMO initiation, 39/95 (41%) were excluded for ECMO and 34/95 (36%) had ECMO initiated out of which 23 patients were admitted alive to the ICU. ECMO-initiation within 60 min was met in 9%. In 6 patients vascular access was complicated, 2 patients had severe bleeding at access site requiring intervention. Survival to discharge among all cases was 25% (24/95). Among patients admitted to ICU on ECMO 39% (9/23) survived to discharge, of these 78% had cerebral performance category scale score 1-2 within 12 months. 8 out of 9 survivors had time from OHCA to ECMO-initiation >60 min. Conclusion: The implementation of an ECPR protocol was feasible without any major, unexpected safety aspects but did not meet the intended target time intervals. Despite this, survival rates were similar to previous studies although most survivors had >60 min to ECMO-initiation. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Jolife AB/Stryker sponsored the study with the loan of LUCAS3 and research funding. Jolife AB/Stryker were not involved in any parts of the study, thus had no impact on study design, management, results nor manuscript.]. (© 2024 The Authors.)
Databáze:	MEDLINE
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