Characteristics of pulmonary artery strain assessed by cardiovascular magnetic resonance imaging and associations with metabolomic pathways in human ageing.

Autor:	Zhang H; Department of Cardiovascular Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Leng S; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Gao F; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Kovalik JP; Duke-NUS Medical School, Singapore, Singapore.; Department of Endocrinology, Singapore General Hospital, Singapore, Singapore., Wee HN; Duke-NUS Medical School, Singapore, Singapore., Chua KV; Duke-NUS Medical School, Singapore, Singapore., Ching J; Duke-NUS Medical School, Singapore, Singapore.; KK Research Centre, KK Women's and Children's Hospital, Singapore, Singapore., Allen JC; Duke-NUS Medical School, Singapore, Singapore., Zhao X; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore., Tan RS; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Wu Q; Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China., Leiner T; Department of Radiology, Mayo Clinic, Rochester, MN, United States., Koh AS; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Zhong L; National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Feb 29; Vol. 11, pp. 1346443. Date of Electronic Publication: 2024 Feb 29 (Print Publication: 2024).
DOI:	10.3389/fcvm.2024.1346443
Abstrakt:	Background: Pulmonary artery (PA) strain is associated with structural and functional alterations of the vessel and is an independent predictor of cardiovascular events. The relationship of PA strain to metabolomics in participants without cardiovascular disease is unknown. Methods: In the current study, community-based older adults, without known cardiovascular disease, underwent simultaneous cine cardiovascular magnetic resonance (CMR) imaging, clinical examination, and serum sampling. PA global longitudinal strain (GLS) analysis was performed by tracking the change in distance from the PA bifurcation to the pulmonary annular centroid, using standard cine CMR images. Circulating metabolites were measured by cross-sectional targeted metabolomics analysis. Results: Among n  = 170 adults (mean age 71 ± 6.3 years old; 79 women), mean values of PA GLS were 16.2 ± 4.4%. PA GLS was significantly associated with age ( β  = -0.13, P  = 0.017), heart rate ( β  =   -0.08, P  = 0.001), dyslipidemia ( β  =   -2.37, P  = 0.005), and cardiovascular risk factors ( β  =   -2.49, P  = 0.001). Alanine ( β  =   -0.007, P  = 0.01) and proline ( β  =   -0.0009, P  = 0.042) were significantly associated with PA GLS after adjustment for clinical risk factors. Medium and long-chain acylcarnitines were significantly associated with PA GLS (C12, P  = 0.027; C12-OH/C10-DC, P  = 0.018; C14:2, P  = 0.036; C14:1, P  = 0.006; C14, P  = 0.006; C14-OH/C12-DC, P  = 0.027; C16:3, P  = 0.019; C16:2, P  = 0.006; C16:1, P  = 0.001; C16:2-OH, P  = 0.016; C16:1-OH/C14:1-DC, P  = 0.028; C18:1-OH/C16:1-DC, P  = 0.032). Conclusion: By conventional CMR, PA GLS was associated with aging and vascular risk factors among a contemporary cohort of older adults. Metabolic pathways involved in PA stiffness may include gluconeogenesis, collagen synthesis, and fatty acid oxidation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (© 2024 Zhang, Leng, Gao, Kovalik, Wee, Chua, Ching, Allen, Zhao, Tan, Wu, Leiner, Koh and Zhong.)
Databáze:	MEDLINE
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