Comorbidities associated with adult asthma: a population-based matched cohort study in Finland.

Autor:	Lemmetyinen RE; Department of Public Health and Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland riikka.lemmetyinen@helsinki.fi., Toppila-Salmi SK; Department of Otorhinolaryngology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.; Department of Allergy, Helsinki University Hospital, Helsinki, Uusimaa, Finland., But A; Department of Public Health, University of Helsinki, Helsinki, Uusimaa, Finland., Renkonen R; Haartman Institute, University of Helsinki, Helsinki, Finland.; HUS Diagnostic Center, Helsinki University Hospital, Helsinki, Uusimaa, Finland., Pekkanen J; Department of Public Health and Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Finnish Institute for Health and Welfare, Helsinki, Uusimaa, Finland., Haukka J; Public Health, University of Helsinki, Helsinki, Uusimaa, Finland., Karjalainen J; Allergy Centre, University of Tampere, Tampere, Pirkanmaa, Finland.; Faculty of Medicine and Health Technology, University of Tampere, Tampere, Pirkanmaa, Finland.
Jazyk:	angličtina
Zdroj:	BMJ open respiratory research [BMJ Open Respir Res] 2024 Mar 14; Vol. 11 (1). Date of Electronic Publication: 2024 Mar 14.
DOI:	10.1136/bmjresp-2023-001959
Abstrakt:	Background: Asthma is a common chronic disease characterised by variable respiratory symptoms and airflow limitation, affecting roughly 4%-10% of the adult population. Adult asthma is associated with higher all-cause mortality compared to individuals without asthma. In this study, we investigate the comorbidities that may affect the management of asthma. Methods: Total of 1648 adults with asthma and 3310 individuals without asthma aged 30-93 were matched with age, gender and area of residency, and followed from 1 January 1997 to 31 December 2013. Baseline information was collected with questionnaires 1997 and follow-up register data from the national discharge registry Finnish Institute for Health and Welfare. Data included diagnoses from outpatient care and day surgery of specialised health care, and data from inpatient care of specialised and primary health care. We included all main diagnoses that had at minimum 200 events and number of diagnoses based on their common appearance with adult asthma. Results: The mean follow-up time varied between 14.2 and 15.1 years, and age at the time of enrolment was 53.9 years for subjects without asthma and 54.4 years for patients with asthma. Chronic obstructive pulmonary disease was 10 times more common among asthmatics. Risk of acute rhinosinusitis, chronic rhinosinusitis with nasal polyps, atopic dermatitis and vocal cord dysfunction was fourfold and risk of pneumonia, and chronic rhinosinusitis was 2.5 times more common among asthmatics. Sleep apnoea, gastro-oesophageal reflux disease, diabetes, allergic rhinitis and dysfunctional breathing were twofold and cataract nearly twofold higher in the asthmatic group. Adult asthma was also significantly associated with musculoskeletal diseases, incontinence and bronchiectasis. Conclusions: The most common and most severe comorbidity of adult asthma in this study was chronic obstructive pulmonary disease. Other common comorbidities of adult asthma include acute rhinosinusitis, chronic rhinosinusitis with nasal polyps, atopic dermatitis, allergic rhinitis, dysfunctional breathing, diabetes, pneumonia, sleep apnoea and gastro-oesophageal reflux disease. Competing Interests: Competing interests: All authors have completed the Unified Competing Interest form (available on request from the corresponding author) and declare: Sanna Toppila-Salmi reports consultancies for ALK-Abelló, AstraZeneca, ERT, GSK, Novartis, Sanofi, and Roche Products outside the submitted work, as well as grant of GSK outside the submitted work. All other authors declare no conflicts of interest. (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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