Comparison of homologous and heterologous inactivated and mRNA vaccination programme against SARS-CoV-2 in dialysis patients.

Autor: Yasar E; Department of Nephrology, Gazi University, Faculty of Medicine, Ankara, Turkey., Yildiz Y; Department of Infectious Disease and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey., Ozturk E; Department of Medical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey., Gok Oguz E; Department of Nephrology, University of Health Sciences, Etlik Ihtisas Training & Research Hospital, Ankara, Turkey., Coskun Yenigun E; Department of Nephrology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey., Ozturk R; Department of Nephrology, University of Health Sciences, Ankara Training & Research Hospital, Ankara, Turkey., Helvaci O; Department of Nephrology, Gazi University, Faculty of Medicine, Ankara, Turkey., Ozger HS; Department of Infectious Disease and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey., Keles M; Department of Nephrology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey., Karacin C; Department of Medical Oncology, University of Health Sciences, Dr Abdurrahman Yurtaslan Oncology Training & Research Hospital, Ankara, Turkey., Ugras Dikmen A; Department of Public Health, Gazi University Faculty of Medicine, Ankara, Turkey., Caglar K; Department of Medical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey., Duranay M; Department of Nephrology, University of Health Sciences, Ankara Training & Research Hospital, Ankara, Turkey., Ayli MD; Department of Nephrology, University of Health Sciences, Etlik Ihtisas Training & Research Hospital, Ankara, Turkey., Dizbay M; Department of Infectious Disease and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey., Erten Y; Department of Nephrology, Gazi University, Faculty of Medicine, Ankara, Turkey., Guz G; Department of Nephrology, Gazi University, Faculty of Medicine, Ankara, Turkey., Derici U; Department of Nephrology, Gazi University, Faculty of Medicine, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2024 Jul; Vol. 29 (7), pp. 405-414. Date of Electronic Publication: 2024 Mar 14.
DOI: 10.1111/nep.14292
Abstrakt: Aim: To evaluate the vaccine response and the effect of the booster dose on COVID-19 positivity in haemodialysis (HD) and peritoneal dialysis (PD) patients who received and did not receive BNT162b2 as a booster dose after two doses of CoronaVac.
Methods: The study included 80 PD and 163 HD patients, who had been administered two doses of the CoronaVac. Antibody levels were measured on Days 42 and 90 after the first dose. Measurements were repeated on Day 181 after the first dose in the patients that received two vaccine doses and on Day 28 after the third dose in those that also received the booster dose. Antibody levels below 50 AU/mL were considered negative.
Results: The seropositivity rate was similar in the HD and PD group on Days 42 and 90 (p = 0.212 and 0.720). All patients were seropositive in the booster group. The antibody level was lower in the patients that received CoronaVac as the booster compared to those administered BNT162b2 in HD and PD groups (p < 0.001 and 0.002). COVID-19 positivity was detected in 11 patients (7 = had not received the booster dose, 4 = had received third dose of CoronaVac). The multivariate analysis revealed that as age increased, COVID-19 positivity also increased (OR: 1.080, 95% CI: 1.017 - 1.146, p = 0.012), while booster dose administration decreased this positivity (OR: 0.113, 95% CI: 0.028 - 0.457, p = 0.002).
Conclusion: Our results may indicate the need for additional vaccination doses in patients with HD and PD. Our findings indicate a higher antibody response in dialysis patients with heterologous BNT162b2 as a booster dose after two doses of CoronaVac compared to homologous CoronaVac.
(© 2024 Asian Pacific Society of Nephrology.)
Databáze: MEDLINE
Externí odkaz: