A humoral stress response protects Drosophila tissues from antimicrobial peptides.

Autor:	Rommelaere S; Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: samuel.rommelaere@epfl.ch., Carboni A; Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Bada Juarez JF; Institute of Bioengineering, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Boquete JP; Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Abriata LA; Institute of Bioengineering, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Teixeira Pinto Meireles F; Institute of Bioengineering, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Rukes V; Institute of Bioengineering, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Vincent C; Department of Biochemistry, School of Biological and Behavioural Sciences, Queen Mary University of London, E1 4NS London, UK., Kondo S; Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, 162-8601 Tokyo, Japan., Dionne MS; Centre for Bacterial Resistance Biology and Department of Life Sciences, Imperial College London, London SW7 2AZ, UK., Dal Peraro M; Institute of Bioengineering, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland., Cao C; Department of Inorganic and Analytical Chemistry, Chemistry and Biochemistry, University of Geneva, 1211 Geneva, Switzerland., Lemaitre B; Global Health Institute, School of Life Science, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. Electronic address: bruno.lemaitre@epfl.ch.
Jazyk:	angličtina
Zdroj:	Current biology : CB [Curr Biol] 2024 Apr 08; Vol. 34 (7), pp. 1426-1437.e6. Date of Electronic Publication: 2024 Mar 13.
DOI:	10.1016/j.cub.2024.02.049
Abstrakt:	7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect the Drosophila respiratory system from AMPs, increasing resilience to stress. Flies lacking Turandot genes are susceptible to environmental stresses due to AMP-induced tracheal apoptosis. Turandot proteins bind to host cell membranes and mask negatively charged phospholipids, protecting them from cationic pore-forming AMPs. Collectively, these data demonstrate that Turandot stress proteins mitigate AMP cytotoxicity to host tissues and therefore improve their efficacy. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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