Glofitamab stimulates immune cell infiltration of CNS tumors and induces clinical responses in secondary CNS lymphoma.

Autor:	Godfrey JK; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Gao L; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Shouse G; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Song JY; Department of Pathology, City of Hope, Duarte, CA., Pak S; Department of Pharmacy, City of Hope, Duarte, CA., Lee B; Department of Pharmacy, City of Hope, Duarte, CA., Chen BT; Department of Diagnostic Radiology, City of Hope, Duarte, CA., Kallam A; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Baird JH; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Marcucci G; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Ghoda L; Department of Hematological Malignancies and Translational Science, Beckman Research Institute of City of Hope, Duarte, CA., Vauleon S; Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Danilov AV; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Herrera AF; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Kwak LW; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA., Budde LE; Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA.
Jazyk:	angličtina
Zdroj:	Blood [Blood] 2024 Jul 25; Vol. 144 (4), pp. 457-461.
DOI:	10.1182/blood.2024024168
Abstrakt:	Abstract: Although CD20×CD3 bispecific antibodies are effective against systemic B-cell lymphomas, their efficacy in central nervous system (CNS) lymphoma is unknown. Here, we report the CD20×CD3 bispecific glofitamab penetrates the blood-brain barrier, stimulates immune-cell infiltration of CNS tumors, and induces clinical responses in patients with secondary CNS. (© 2024 American Society of Hematology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.)
Databáze:	MEDLINE
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