Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure.

Autor:	Eckle T; Department of Anesthesiology (T.E., J.B.), University of Colorado Anschutz Medical Campus, Aurora.; Division of Cardiology, Department of Medicine (T.E., L.A.W.), University of Colorado Anschutz Medical Campus, Aurora., Bertazzo J; Department of Anesthesiology (T.E., J.B.), University of Colorado Anschutz Medical Campus, Aurora., Khatua TN; Department of Biomedical Sciences, Centre for Cardiovascular Investigations, University of Guelph, ON, Canada (T.N.K., S.R.F.T., N.M.B., T.A.M.)., Fatemi Tabatabaei SR; Department of Biomedical Sciences, Centre for Cardiovascular Investigations, University of Guelph, ON, Canada (T.N.K., S.R.F.T., N.M.B., T.A.M.)., Moori Bakhtiari N; Department of Biomedical Sciences, Centre for Cardiovascular Investigations, University of Guelph, ON, Canada (T.N.K., S.R.F.T., N.M.B., T.A.M.)., Walker LA; Division of Cardiology, Department of Medicine (T.E., L.A.W.), University of Colorado Anschutz Medical Campus, Aurora., Martino TA; Department of Biomedical Sciences, Centre for Cardiovascular Investigations, University of Guelph, ON, Canada (T.N.K., S.R.F.T., N.M.B., T.A.M.).
Jazyk:	angličtina
Zdroj:	Circulation research [Circ Res] 2024 Mar 15; Vol. 134 (6), pp. 675-694. Date of Electronic Publication: 2024 Mar 14.
DOI:	10.1161/CIRCRESAHA.123.323522
Abstrakt:	The impact of circadian rhythms on cardiovascular function and disease development is well established, with numerous studies in genetically modified animals emphasizing the circadian molecular clock's significance in the pathogenesis and pathophysiology of myocardial ischemia and heart failure progression. However, translational preclinical studies targeting the heart's circadian biology are just now emerging and are leading to the development of a novel field of medicine termed circadian medicine. In this review, we explore circadian molecular mechanisms and novel therapies, including (1) intense light, (2) small molecules modulating the circadian mechanism, and (3) chronotherapies such as cardiovascular drugs and meal timings. These promise significant clinical translation in circadian medicine for cardiovascular disease. (4) Additionally, we address the differential functioning of the circadian mechanism in males versus females, emphasizing the consideration of biological sex, gender, and aging in circadian therapies for cardiovascular disease. Competing Interests: T.A. Martino is a career investigator of the Heart and Stroke Foundation of Canada and the distinguished chair in molecular cardiovascular research at the University of Guelph, ON, Canada. The other authors report no conflicts.
Databáze:	MEDLINE
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