Impact of Smoking on Coronary Volume-to-Myocardial Mass Ratio: An ADVANCE Registry Substudy.

Autor:	Holmes KR; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Gulsin GS; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Fairbairn TA; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Hurwitz-Koweek L; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Matsuo H; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Nørgaard BL; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Jensen JM; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Sand NR; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Nieman K; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Bax JJ; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Pontone G; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Chinnaiyan KM; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Rabbat MG; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Amano T; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Kawasaki T; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Akasaka T; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Kitabata H; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Rogers C; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Patel MR; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Payne GW; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Leipsic JA; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.)., Sellers SL; From the Department of Radiology (K.R.H., G.S.G., J.A.L., S.L.S.) and Centre for Heart Lung Innovation & Providence Research (G.S.G., J.A.L., S.L.S.), St Paul's Hospital and University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6; Liverpool Heart and Chest Hospital, Liverpool, England (T.A.F.); Department of Radiology, Duke University School of Medicine, Durham, NC (L.H.K., M.R.P.); Wakayama Medical University, Wakayama, Japan (H.M., T. Akasaka, H.K.); Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark (B.L.N., J.M.J.); Department of Cardiology, University Hospital of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark (N.P.R.S.); Erasmus Medical Center, Rotterdam, the Netherlands (K.N.); Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands (J.J.B.); Centro Cardiologico Monzino, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), University of Milan, Milan, Italy (G.P.); William Beaumont Hospital, Royal Oak, Mich (K.M.C.); Loyola University Medical Center, Maywood, Ill (M.G.R.); Aichi Medical University, Aichi, Japan (T. Amano); Department of Cardiology, Shin Koga Hospital, Fukuoka, Japan (T.K.); HeartFlow, Redwood City, Calif (C.R.); and University of Northern British Columbia, Prince George, British Columbia, Canada (G.W.P.).
Jazyk:	angličtina
Zdroj:	Radiology. Cardiothoracic imaging [Radiol Cardiothorac Imaging] 2024 Apr; Vol. 6 (2), pp. e220197.
DOI:	10.1148/ryct.220197
Abstrakt:	Purpose To examine the relationship between smoking status and coronary volume-to-myocardial mass ratio (V/M) among individuals with coronary artery disease (CAD) undergoing CT fractional flow reserve (CT-FFR) analysis. Materials and Methods In this secondary analysis, participants from the ADVANCE registry evaluated for suspected CAD from July 15, 2015, to October 20, 2017, who were found to have coronary stenosis of 30% or greater at coronary CT angiography (CCTA) were included if they had known smoking status and underwent CT-FFR and V/M analysis. CCTA images were segmented to calculate coronary volume and myocardial mass. V/M was compared between smoking groups, and predictors of low V/M were determined. Results The sample for analysis included 503 current smokers, 1060 former smokers, and 1311 never-smokers (2874 participants; 1906 male participants). After adjustment for demographic and clinical factors, former smokers had greater coronary volume than never-smokers (former smokers, 3021.7 mm 3 ± 934.0 [SD]; never-smokers, 2967.6 mm 3 ± 978.0; P = .002), while current smokers had increased myocardial mass compared with never-smokers (current smokers, 127.8 g ± 32.9; never-smokers, 118.0 g ± 32.5; P = .02). However, both current and former smokers had lower V/M than never-smokers (current smokers, 24.1 mm 3 /g ± 7.9; former smokers, 24.9 mm 3 /g ± 7.1; never-smokers, 25.8 mm 3 /g ± 7.4; P < .001 [unadjusted] and P = .002 [unadjusted], respectively). Current smoking status (odds ratio [OR], 0.74 [95% CI: 0.59, 0.93]; P = .009), former smoking status (OR, 0.81 [95% CI: 0.68, 0.97]; P = .02), stenosis of 50% or greater (OR, 0.62 [95% CI: 0.52, 0.74]; P < .001), and diabetes (OR, 0.67 [95% CI: 0.56, 0.82]; P < .001) were independent predictors of low V/M. Conclusion Both current and former smoking status were independently associated with low V/M. Keywords: CT Angiography, Cardiac, Heart, Ischemia/Infarction Clinical trial registration no. NCT02499679 Supplemental material is available for this article . © RSNA, 2024.
Databáze:	MEDLINE
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