Direct-acting antivirals in women of reproductive age infected with hepatitis C virus.

Autor: Dobrowolska K; Collegium Medicum, Jan Kochanowski University, Kielce, Poland., Pawłowska M; Department of Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland., Zarębska-Michaluk D; Department of Infectious Diseases and Allergology, Jan Kochanowski University, Kielce, Poland., Rzymski P; Department of Environmental Medicine, Poznań University of Medical Sciences, Poznań, Poland., Janczewska E; Department of Basic Medical Sciences, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland., Tudrujek-Zdunek M; Department of Infectious Diseases, Medical University of Lublin, Lublin, Poland., Berak H; Outpatient Clinic, Hospital for Infectious Diseases in Warsaw, Warsaw, Poland., Mazur W; Clinical Department of Infectious Diseases in Chorzów, Medical University of Silesia, Katowice, Poland., Klapaczyński J; Department of Internal Medicine and Hepatology, The National Institute of Medicine of the Ministry of Interior and Administration, Warszawa, Poland., Lorenc B; Pomeranian Center of Infectious Diseases, Medical University, Gdańsk, Poland., Janocha-Litwin J; Department of Infectious Diseases and Hepatology, Wrocław Medical University, Wrocław, Poland., Parfieniuk-Kowerda A; Department of Infectious Diseases and Hepatology, Medical University of Białystok, Białystok, Poland., Dybowska D; Department of Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland., Piekarska A; Department of Infectious Diseases and Hepatology, Medical University of Łódź, Łódź, Poland., Krygier R; Outpatients Hepatology Department, State University of Applied Sciences, Konin, Poland., Dobracka B; MedicalSpec Medical Center, Wrocław, Poland., Jaroszewicz J; Department of Infectious Diseases and Hepatology, Medical University of Silesia in Katowice, Bytom, Poland., Flisiak R; Department of Infectious Diseases and Hepatology, Medical University of Białystok, Białystok, Poland.
Jazyk: angličtina
Zdroj: Journal of viral hepatitis [J Viral Hepat] 2024 Jun; Vol. 31 (6), pp. 309-319. Date of Electronic Publication: 2024 Mar 14.
DOI: 10.1111/jvh.13936
Abstrakt: Eliminating hepatitis C virus (HCV) infection in the population of women of reproductive age is important not only for the health of women themselves but also for the health of newborns. This study aimed to evaluate the implementation of this goal by analysing the effectiveness of contemporary therapy in a large cohort from everyday clinical practice along with identifying factors reducing therapeutic success. The analysed population consisted of 7861 patients, including 3388 women aged 15-49, treated in 2015-2022 in 26 hepatology centres. Data were collected retrospectively using a nationwide EpiTer-2 database. Females were significantly less often infected with HCV genotype 3 compared to males (11.2% vs. 15.7%) and less frequently showed comorbidities (40.5% vs. 44.2%) and comedications (37.2% vs. 45.2%). Hepatocellular carcinoma, liver transplantation, HIV and HBV coinfections were reported significantly less frequently in women. Regardless of the treatment type, females significantly more often reached sustained virologic response (98.8%) compared to males (96.8%). Regardless of gender, genotype 3 and cirrhosis were independent factors increasing the risk of treatment failure. Women more commonly reported adverse events, but death occurred significantly more frequently in men (0.3% vs. 0.1%), usually related to underlying advanced liver disease. We have demonstrated excellent effectiveness and safety profiles for treating HCV infection in women. This gives hope for the micro-elimination of HCV infections in women, translating into a reduced risk of severe disease in both women and their children.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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