Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease.

Autor:	Giacona JM; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.; Department of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Afridi A; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Bezan Petric U; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Johnson T; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Pastor J; Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Ren J; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States.; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Sandon L; Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Malloy C; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.; Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States.; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Pandey A; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Shah A; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Berry JD; Department of Internal Medicine, University of Texas Health Science Center at Tyler, Tyler, Texas, United States., Moe OW; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.; Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States.; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States., Vongpatanasin W; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States.; Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States.
Jazyk:	angličtina
Zdroj:	Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2024 Apr 01; Vol. 136 (4), pp. 1007-1014. Date of Electronic Publication: 2024 Mar 14.
DOI:	10.1152/japplphysiol.00818.2023
Abstrakt:	Highly bioavailable inorganic phosphate (Pi) is present in large quantities in the typical Western diet and represents a large fraction of total phosphate intake. Dietary Pi excess induces exercise intolerance and skeletal muscle mitochondrial dysfunction in normal mice. However, the relevance of this to humans remains unknown. The study was conducted on 13 individuals without a history of cardiopulmonary disease (46% female, 15% Black participants) enrolled in the pilot-phase of the Dallas Heart and Mind Study. Total dietary phosphate was estimated from 24-h dietary recall (ASA24). Muscle ATP synthesis was measured at rest, and phosphocreatinine (PCr) dynamics was measured during plantar flexion exercise using 7-T 31 P magnetic resonance (MR) spectroscopy in the calf muscle. Correlation was assessed between dietary phosphate intake normalized to total caloric intake, resting ATP synthesis, and PCr depletion during exercise. Higher dietary phosphate intake was associated with lower resting ATP synthesis ( r = -0.62, P = 0.03), and with higher levels of PCr depletion during plantar flexion exercise relative to the resting period ( r = -0.72; P = 0.004). These associations remain significant after adjustment for age and estimated glomerular filtration rate (both P < 0.05). High dietary phosphate intake was also associated with lower serum Klotho levels, and Klotho levels are in turn associated with PCr depletion and higher ADP accumulation post exercise. Our study suggests that higher dietary phosphate is associated with reduced skeletal muscle mitochondrial function at rest and exercise in humans providing new insight into potential mechanisms linking the Western diet to impaired energy metabolism. NEW & NOTEWORTHY This is the first translational research study directly demonstrating the adverse effects of dietary phosphate on muscle energy metabolism in humans. Importantly, our data show that dietary phosphate is associated with impaired muscle ATP synthesis at rest and during exercise, independent of age and renal function. This is a new biologic paradigm with significant clinical dietary implications.
Databáze:	MEDLINE
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