Multisystem inflammatory syndrome in children (MIS-C) post-COVID-19 in Iran: clinical profile, cardiac features, and outcomes.

Autor: Hoseininasab A; Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran., Sinaei R; Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.; Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Bagheri MM; Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Ahmadipour M; Department of Pediatrics, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Derakhshan R; School of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Najafzadeh MJ; School of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Robati FK; Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran., Jafari M; Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. mjafari@kmu.ac.ir.; Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran. mjafari@kmu.ac.ir., Ebrahimi S; Department of Pediatrics, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran., Jafari MA; Department of Veterinary Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Jazyk: angličtina
Zdroj: BMC pediatrics [BMC Pediatr] 2024 Mar 13; Vol. 24 (1), pp. 179. Date of Electronic Publication: 2024 Mar 13.
DOI: 10.1186/s12887-024-04652-y
Abstrakt: Background: In April 2020, an association between multisystem inflammatory syndromes (MIS-C) was observed in children with severe acute respiratory syndrome coronavirus infection (SARS-CoV-2). Most patients had heart involvement alone, and most patients had pericardial effusion. This study aimed to express and emphasize cardiac involvement in pediatric patients with respiratory symptoms who were diagnosed with COVID-19.
Methods: This study was conducted in July 2021 in Kerman province, Southeastern Iran, during a notable surge in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. The study included 904 pediatric patients diagnosed with COVID-19. Data collection involved a comprehensive assessment of clinical symptoms and manifestations. Patients with fever lasting more than five days were admitted to the hospital. Echocardiography was utilized for cardiac involvement diagnosis, with 47 patients undergoing this diagnostic procedure.
Results: Of the 904 patients, most of them had high fevers (74%). Fifty-five patients had a fever for more than five days and were hospitalized. Of the 47 patients who underwent echocardiography, 45 (81%) had heart involvement. In 75% of patients, pericardial effusion was the only cardiac involvement. Patients with pericardial effusion were treated with dexamethasone up to 3 mg every 8 h for 72 h.
Conclusions: MIS-C has a wide range of clinical symptoms. In cases where the fever is prolonged and there are gastrointestinal symptoms, physicians have clinical suspicion to diagnose this syndrome. Most cases of pericardial effusion are alone and improve with treatment with glucocorticosteroids.
(© 2024. The Author(s).)
Databáze: MEDLINE
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