Screening for liver fibrosis: lessons from colorectal and lung cancer screening.

Autor: Thiele M; Centre for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Kamath PS; Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA., Graupera I; Liver Unit Hospital Clínic, Barcelona, Catalonia, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Catalonia, Spain.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain., Castells A; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Catalonia, Spain.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain.; Department of Gastroenterology, Hospital Clínic, Barcelona, Catalonia, Spain., de Koning HJ; Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands., Serra-Burriel M; Epidemiology, Statistics, and Prevention Institute, University of Zurich, Zurich, Switzerland., Lammert F; Department of Medicine II, Saarland University Medical Center, Homburg, Germany.; Hannover Medical School (MHH), Hannover, Germany., Ginès P; Liver Unit Hospital Clínic, Barcelona, Catalonia, Spain. pgines@clinic.cat.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain. pgines@clinic.cat.; Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona, Catalonia, Spain. pgines@clinic.cat.; Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain. pgines@clinic.cat.
Jazyk: angličtina
Zdroj: Nature reviews. Gastroenterology & hepatology [Nat Rev Gastroenterol Hepatol] 2024 Jul; Vol. 21 (7), pp. 517-527. Date of Electronic Publication: 2024 Mar 13.
DOI: 10.1038/s41575-024-00907-2
Abstrakt: Many countries have incorporated population screening programmes for cancer, such as colorectal and lung cancer, into their health-care systems. Cirrhosis is more prevalent than colorectal cancer and has a comparable age-standardized mortality rate to lung cancer. Despite this fact, there are no screening programmes in place for early detection of liver fibrosis, the precursor of cirrhosis. In this Perspective, we use insights from colorectal and lung cancer screening to explore the benefits, challenges, implementation strategies and pathways for future liver fibrosis screening initiatives. Several non-invasive methods and referral pathways for early identification of liver fibrosis exist, but in addition to accurate detection, screening programmes must also be cost-effective and demonstrate benefit through a reduction in liver-related mortality. Randomized controlled trials are needed to confirm this. Future randomized screening trials should evaluate not only the screening tests, but also interventions used to halt disease progression in individuals identified through screening.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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