Facile synthesis of Fe 2 O 3 , Fe 2 O 3 @CuO and WO 3 nanoparticles: characterization, structure determination and evaluation of their biological activity.

Autor: Mohamed AT; Nanotechnology Research Center (NTRC), The British University in Egypt, El-Shorouk City, Suez Desert Road, P.O. Box 43, Cairo, 11837, Egypt., Hameed RA; Basic Science Department, Preparatory Year, University of Ha'il, 1560, Hail, Saudi Arabia.; Medical and Diagnostic Research Centre, University of Ha'il, 55473, Ha'il, Saudi Arabia., El-Moslamy SH; Bioprocess Development Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg Al-Arab City, 21934, Alexandria, Egypt., Fareid M; Basic Science Department, Preparatory Year, University of Ha'il, 1560, Hail, Saudi Arabia.; Medical and Diagnostic Research Centre, University of Ha'il, 55473, Ha'il, Saudi Arabia., Othman M; Basic Science Department, Preparatory Year, University of Ha'il, 1560, Hail, Saudi Arabia.; Medical and Diagnostic Research Centre, University of Ha'il, 55473, Ha'il, Saudi Arabia., Loutfy SA; Nanotechnology Research Center (NTRC), The British University in Egypt, El-Shorouk City, Suez Desert Road, P.O. Box 43, Cairo, 11837, Egypt.; Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute (NCI), Cairo University, Fom El-Khalig, 11796, Cairo, Egypt., Kamoun EA; Nanotechnology Research Center (NTRC), The British University in Egypt, El-Shorouk City, Suez Desert Road, P.O. Box 43, Cairo, 11837, Egypt. badawykamoun@yahoo.com.; Department of Chemistry, College of Science, King Faisal University, 31982, Al-Ahsa, Saudi Arabia. badawykamoun@yahoo.com.; Polymeric Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications, New Borg Al-Arab City, 21934, Alexandria, Egypt. badawykamoun@yahoo.com., Elnouby M; Nanotechnology and Composite Materials Department, Advanced Technology and New Materials Research (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg Al-Arab City, 21934, Alexandria, Egypt. m_nano2050@yahoo.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Mar 13; Vol. 14 (1), pp. 6081. Date of Electronic Publication: 2024 Mar 13.
DOI: 10.1038/s41598-024-55319-8
Abstrakt: Due to their high specific surface area and its characteristic's functionalized nanomaterials have great potential in medical applications specialty, as an anticancer. Herein, functional nanoparticles (NPs) based on iron oxide Fe 2 O 3 , iron oxide modified with copper oxide Fe 2 O 3 @CuO, and tungsten oxide WO 3 were facile synthesized for biomedical applications. The obtained nanomaterials have nanocrystal sizes of 35.5 nm for Fe 2 O 3 , 7 nm for Fe 2 O 3 @CuO, and 25.5 nm for WO 3 . In addition to octahedral and square nanoplates for Fe 2 O 3 , and WO 3; respectively. Results revealed that Fe 2 O 3 , Fe 2 O 3 @CuO, and WO 3 NPs showed remarked anticancer effects versus a safe effect on normal cells through cytotoxicity test using MTT-assay. Notably, synthesized NPs e.g. our result demonstrated that Fe 2 O 3 @CuO exhibited the lowest IC 50 value on the MCF-7 cancer cell line at about 8.876 µg/ml, compared to Fe 2 O 3 was 12.87 µg/ml and WO 3 was 9.211 µg/ml which indicate that the modification NPs Fe 2 O 3 @CuO gave the highest antiproliferative effect against breast cancer. However, these NPs showed a safe mode toward the Vero normal cell line, where IC 50 were monitored as 40.24 µg/ml for Fe 2 O 3 , 21.13 µg/ml for Fe 2 O 3 @CuO, and 25.41 µg/ml for WO 3 NPs. For further evidence. The antiviral activity using virucidal and viral adsorption mechanisms gave practiced effect by viral adsorption mechanism and prevented the virus from replicating inside the cells. Fe 2 O 3 @CuO and WO 3 NPs showed a complete reduction in the viral load synergistic effect of combinations between the tested two materials copper oxide instead of iron oxide alone. Interestingly, the antimicrobial efficiency of Fe 2 O 3 @CuO NPs, Fe 2 O 3 NPs, and WO 3 NPs was evaluated using E. coli, S. aureus, and C. albicans pathogens. The widest microbial inhibition zone (ca. 38.45 mm) was observed with 250 mg/ml of WO 3 NPs against E. coli, whereas using 40 mg/ml of Fe 2 O 3 @CuO NPS could form microbial inhibition zone ca. 32.86 mm against S. aureus. Nevertheless, C. albicans was relatively resistant to all examined NPs. The superior biomedical activities of these nanostructures might be due to their unique features and accepted evaluations.
(© 2024. The Author(s).)
Databáze: MEDLINE
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