Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion.

Autor: Planas D; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France. delphine.planas@pasteur.fr.; Vaccine Research Institute, Créteil, France. delphine.planas@pasteur.fr., Staropoli I; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Michel V; Pathogenesis of Vascular Infections Unit, Institut Pasteur, INSERM, Paris, France., Lemoine F; G5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, Université Paris Cité, Paris, France.; Bioinformatics and Biostatistics Hub, Paris, France., Donati F; G5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, Université Paris Cité, Paris, France.; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France., Prot M; G5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, Université Paris Cité, Paris, France., Porrot F; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Guivel-Benhassine F; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Jeyarajah B; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France., Brisebarre A; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France., Dehan O; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France., Avon L; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France., Bolland WH; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Hubert M; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Buchrieser J; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Vanhoucke T; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France., Rosenbaum P; Humoral Immunology Laboratory, Institut Pasteur, Université Paris Cité, INSERM U1222, Paris, France., Veyer D; Laboratoire de Virologie, Service de Microbiologie, Hôpital Européen Georges Pompidou, Paris, France.; Functional Genomics of Solid Tumors (FunGeST), Centre de Recherche des Cordeliers, INSERM, Université de Paris, Sorbonne Université, Paris, France., Péré H; Laboratoire de Virologie, Service de Microbiologie, Hôpital Européen Georges Pompidou, Paris, France.; Functional Genomics of Solid Tumors (FunGeST), Centre de Recherche des Cordeliers, INSERM, Université de Paris, Sorbonne Université, Paris, France., Lina B; Laboratoire de Virologie, Institut des Agents Infectieux, Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.; CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, Lyon, France., Trouillet-Assant S; Laboratoire de Virologie, Institut des Agents Infectieux, Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.; CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, Lyon, France., Hocqueloux L; CHU d'Orléans, Service de Maladies Infectieuses, Orléans, France., Prazuck T; CHU d'Orléans, Service de Maladies Infectieuses, Orléans, France., Simon-Loriere E; G5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, Université Paris Cité, Paris, France. etienne.simon-loriere@pasteur.fr.; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France. etienne.simon-loriere@pasteur.fr., Schwartz O; Virus and Immunity Unit, Institut Pasteur, Université Paris Cité, CNRS UMR3569, Paris, France. olivier.schwartz@pasteur.fr.; Vaccine Research Institute, Créteil, France. olivier.schwartz@pasteur.fr.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Mar 13; Vol. 15 (1), pp. 2254. Date of Electronic Publication: 2024 Mar 13.
DOI: 10.1038/s41467-024-46490-7
Abstrakt: The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral sublineages. Here, we isolate and characterize XBB.1, XBB.1.5, XBB.1.9.1, XBB.1.16.1, EG.5.1.1, EG.5.1.3, XBF, BA.2.86.1 and JN.1 variants, representing >80% of circulating variants in January 2024. The XBB subvariants carry few but recurrent mutations in the spike, whereas BA.2.86.1 and JN.1 harbor >30 additional changes. These variants replicate in IGROV-1 but no longer in Vero E6 and are not markedly fusogenic. They potently infect nasal epithelial cells, with EG.5.1.3 exhibiting the highest fitness. Antivirals remain active. Neutralizing antibody (NAb) responses from vaccinees and BA.1/BA.2-infected individuals are markedly lower compared to BA.1, without major differences between variants. An XBB breakthrough infection enhances NAb responses against both XBB and BA.2.86 variants. JN.1 displays lower affinity to ACE2 and higher immune evasion properties compared to BA.2.86.1. Thus, while distinct, the evolutionary trajectory of these variants combines increased fitness and antibody evasion.
(© 2024. The Author(s).)
Databáze: MEDLINE
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