Stabilin-2 mediated apoptotic cell phagocytosis induces interleukin-10 expression by p38 and Pbx1 signaling.

Autor: Jo HS; Department of Physiology, Cell and Matrix Research Institute, Kyungpook National University, School of Medicine, Daegu, South Korea. hanseul6146@gmail.com., Kim HJ; Department of Physiology, Cell and Matrix Research Institute, Kyungpook National University, School of Medicine, Daegu, South Korea. kimhajeong@knu.ac.kr.
Jazyk: angličtina
Zdroj: Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Jun; Vol. 82 (2), pp. 919-925. Date of Electronic Publication: 2024 Mar 13.
DOI: 10.1007/s12013-024-01243-7
Abstrakt: Apoptotic cell death occurs under normal physiological conditions, such as development, tissue remodeling, and inflammation. Appropriate removal of apoptotic cells by phagocytes and the secretion of anti-inflammatory cytokines such as IL-10 are important mechanisms for maintaining tissue homeostasis. Apoptotic cell phagocytosis is mediated by several phosphatidylserine recognition receptors on non-professional or professional phagocytes, such as neighboring epithelial cells or macrophages. Stabilin-2 is reported as a phosphatidylserine recognition receptor for apoptotic cell phagocytosis, and its downstream signaling pathway for cytoskeletal rearrangement for phagocytosis is well known. However, the mechanisms for stabilin-2-mediated IL-10 production has not yet been reported. In this study, we aimed to investigate stabilin-2 receptor-mediated IL-10 transcription regulation signaling pathway.
(© 2024. The Author(s).)
Databáze: MEDLINE
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