Surgical incision pain induced an increase in alcohol consumption in mice.

Autor: Ghani S; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA., Alkhlaif Y; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA., Mann J; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA., Moncayo L; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA., Ulker E; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA., Caillaud M; Nantes Université, INSERM, UMR1235-TENS, The Enteric Nervous System in Gut and Brain Diseases, Nantes, France., Barik M; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA., Ditre JW; Department of Psychology, Syracuse University, Syracuse, NY, USA., Miles MF; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA., Damaj MI; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA; Translational Research Initiative for Pain and Neuropathy, Virginia Commonwealth University, USA. Electronic address: m.damaj@vcuhealth.org.
Jazyk: angličtina
Zdroj: Alcohol (Fayetteville, N.Y.) [Alcohol] 2024 Jun; Vol. 117, pp. 1-9. Date of Electronic Publication: 2024 Mar 11.
DOI: 10.1016/j.alcohol.2024.03.005
Abstrakt: Introduction: Large population-based studies have suggested a link between increased alcohol use and reduced pain. In addition, these studies suggest that higher levels of pain intensity are associated with an increase in alcohol consumption and rates of hazardous drinking which potentiates the risk of developing alcohol use disorders (AUD). The mechanisms and determinants of the alcohol-pain interaction can be studied in preclinical studies.
Methods: The overall goal of this study is to use animal models to explore the impact of acute postoperative pain on alcohol intake. To achieve this, we characterized the timeline and levels of alcohol intake and preference in mice after laparotomy in the 2-bottle choice paradigm.
Results: Our results show that laparotomy surgery increased alcohol intake and preference in male mice but not females in the 2-bottle choice and 3-bottle choice assays. In addition, ketoprofen administration blocked the increase in alcohol consumption in male mice after laparotomy. We also found that changes in alcohol initial sensitivity and acute functional tolerance, using loss of righting reflex (LORR) response, occur after surgery in mice.
Conclusion: Taken together, these findings suggests that sex, pain and alcohol sensitivity-related factors may modulate the relationship between alcohol consumption and pain.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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