IL-4 regulates neutrophilic pulmonary inflammation in a mouse model of bronchial asthma.

Autor: Shilovskiy IP; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation. Electronic address: igorshilovski@gmail.com., Nikolskii AA; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation., Timotievich ED; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation., Kovchina VI; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation., Vishnyakova LI; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation., Yumashev KV; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation., Vinogradova KV; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation; Federal State Budgetary Educational Institution of Higher Education «Moscow state Academy of Veterinary Medicine and Biotechnology - MVA by K.I. Skryabin» of the Ministry of Agriculture of the Russian Federation, 109472, 23, Academician Scriabin St., Moscow, Russian Federation., Kaganova MM; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation; Federal State Budgetary Educational Institution of Higher Education «Moscow state Academy of Veterinary Medicine and Biotechnology - MVA by K.I. Skryabin» of the Ministry of Agriculture of the Russian Federation, 109472, 23, Academician Scriabin St., Moscow, Russian Federation., Brylina VE; Federal State Budgetary Educational Institution of Higher Education «Moscow state Academy of Veterinary Medicine and Biotechnology - MVA by K.I. Skryabin» of the Ministry of Agriculture of the Russian Federation, 109472, 23, Academician Scriabin St., Moscow, Russian Federation., Tyulyubaev VV; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenovskiy University), 119991, 2/4, Bolshaya Pirogovskaya, St., Moscow, Russian Federation., Rusak TE; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation; Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenovskiy University), 119991, 2/4, Bolshaya Pirogovskaya, St., Moscow, Russian Federation., Dyneva ME; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation., Kurbacheva OM; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation., Kudlay DA; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation., Khaitov MR; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, 115522, 24, Kashirskoe shosse, Moscow, Russian Federation; Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation, 117997, 1, Ostrovityanova St., Moscow, Russian Federation.
Jazyk: angličtina
Zdroj: Cytokine [Cytokine] 2024 Jun; Vol. 178, pp. 156563. Date of Electronic Publication: 2024 Mar 12.
DOI: 10.1016/j.cyto.2024.156563
Abstrakt: Neutrophilic pulmonary inflammation in asthmatics substantially exacerbates the severity of the disease leading to resistance to conventional corticosteroid therapy. Many studies established the involvement of Th1- and Th17-cells and cytokines produced by them (IFNg, IL-17A, IL-17F etc.) in neutrophilic pulmonary inflammation. Recent studies revealed that IL-4 - a Th2-cytokine regulates neutrophil effector functions and migration. It was showed that IL-4 substantially reduces neutrophilic inflammation of the skin in a mouse model of cutaneous bacterial infection and blood neutrophilia in a mouse model systemic bacterial infection. However, there are no data available regarding the influence of IL-4 on non-infectious pulmonary inflammation. In the current study we investigated the effects of IL-4 in a previously developed mouse model of neutrophilic bronchial asthma. We showed that systemic administration of IL-4 significantly restricts neutrophilic inflammation of the respiratory tract probably through the suppression of Th1-/Th17-immune responses and downregulation of CXCR2. Additionally, pulmonary neutrophilic inflammation could be alleviated by IL-4-dependant polarization of N2 neutrophils and M2 macrophages, expressing anti-inflammatory TGFβ. Considering these, IL-4 might be used for reduction of exaggerated pulmonary neutrophilic inflammation and overcoming corticosteroid insensitivity of asthma patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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