Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance.

Autor: Dabbaghipour R; Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran AND Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. dabaghipourreza@gmail.com., Ahmadi E; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. ahmadi4bio@gmail.com., Entezam M; Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran. entezam@sums.ac.ir., Rahbar Farzam O; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. omid.rahbar.farzam@gmail.com., Baghbanzadeh A; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. amirbaghbanzadeh@gmail.com., Saber Sichani A; Department of Biology, Texas A&M University, College Station, TX, USA. alisaber.as1996@gmail.com., Jalilzadeh N; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. jalilzadehnazila@gmail.com., Jafarlou M; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Mehdijafarlou@gmail.com., Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. behzad_im@yahoo.com.
Jazyk: angličtina
Zdroj: Iranian journal of allergy, asthma, and immunology [Iran J Allergy Asthma Immunol] 2023 Dec 28; Vol. 22 (6), pp. 512-526. Date of Electronic Publication: 2023 Dec 28.
DOI: 10.18502/ijaai.v22i6.14641
Abstrakt: Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio. In this review study, we overviewed the association between LncRNAs and Th17/Treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.
Databáze: MEDLINE