Immunization against covid-19 and mortality in hospitalized patients: a retrospective cohort.

Autor:	Figueiredo AM; Universidade Federal da Paraíba. Centro de Ciências Médicas. Departamento de Promoção da Saúde. João Pessoa, PB, Brasil.; Universidade Federal da Paraíba. Departamento de Estatística. Programa de Pós-Graduação em Modelos de Decisão em Saúde. João Pessoa, PB, Brasil., Massuda A; Fundação Getulio Vargas. Escola de Administração de Empresas do Estado de São Paulo. Centro de Estudos de Planejamento e Gestão em Saúde (FGV-Saúde). São Paulo, SP, Brasil., Fernandez M; Universidade de Brasília. Instituto de Ciência Política. Brasília, DF, Brasil., Medeiros Neto AH; Universidade Federal da Paraíba. Centro de Ciências Médicas. Departamento de Doenças Infecciosas, Parasitárias e Inflamatórias. João Pessoa, PB, Brasil., Carvalho M; Universidade Federal da Paraíba. Centro de Ciências Aplicadas e Educação. Departamento de Ciências Exatas. Rio Tinto, PB, Brasil.
Jazyk:	English; Portuguese
Zdroj:	Revista de saude publica [Rev Saude Publica] 2024 Mar 11; Vol. 58, pp. 07. Date of Electronic Publication: 2024 Mar 11 (Print Publication: 2024).
DOI:	10.11606/s1518-8787.2024058005476
Abstrakt:	Objective: To evaluate the effectiveness of vaccines developed against covid-19 in reducing mortality in people hospitalized with severe acute respiratory syndrome (SARS) caused by SARS-CoV-2. Methods: This is a retrospective cohort that evaluated risk factors and the effectiveness of the two-dose vaccination schedule in reducing the mortality of people hospitalized for covid-19 in the state of Paraíba from February to November 2021. The explanatory variables were vaccination status, presence of comorbidities, socioeconomic and demographic characteristics. Descriptive analyses and bivariate and multivariable logistic regression were performed. Results: Most hospitalizations and deaths occurred until May 2021. The percentage of patients with a complete vaccination schedule was similar across patients admitted to public and private hospitals and higher in residents of less developed municipalities. Multivariable analysis demonstrated that women (OR = 0.896; 95%CI 0.830-0.967) and people admitted to private hospitals (OR = 0.756; 95%CI 0.679-0.842) were less likely to die. Presence of any comorbidity (OR = 1.627; 95%CI 1.500-1.765) and age ≥ 80 years (OR = 7.426; 95%CI 6.309-8.741) were risk factors for death. Patients with complete vaccination schedule at the time of admission were 41.7% less likely to die (OR = 0.583; 95% CI 0.501-0.679) from covid-19 in the adjusted analysis, as compared to unvaccinated patients. Conclusions: The study reveals that immunization was effective in reducing the likelihood of death from covid-19. The results suggest that greater vaccination coverage in the first half of 2021 would prevent thousands of deaths in the country.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu