Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report.

Autor: Palakshappa JA; Wake Forest University School of Medicine, Winston-Salem, North Carolina., Batt JAE; University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada., Bodine SC; Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma.; Oklahoma City Veterans Affairs Medical Center, Oklahoma City, Oklahoma., Connolly BA; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University, Belfast, United Kingdom., Doles J; Indiana University School of Medicine, Indianapolis, Indiana., Falvey JR; University of Maryland School of Medicine, Baltimore, Maryland., Ferrante LE; Yale University School of Medicine, New Haven, Connecticut., Files DC; Wake Forest University School of Medicine, Winston-Salem, North Carolina., Harhay MO; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Harrell K, Hippensteel JA; University of Colorado School of Medicine, Aurora, Colorado., Iwashyna TJ; Johns Hopkins University School of Medicine, Baltimore, Maryland., Jackson JC; Vanderbilt University School of Medicine, Nashville, Tennessee., Lane-Fall MB; University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Monje M; Howard Hughes Medical Institute, Stanford University, Stanford, California., Moss M; University of Colorado School of Medicine, Aurora, Colorado., Needham DM; Johns Hopkins University School of Medicine, Baltimore, Maryland., Semler MW; Vanderbilt University School of Medicine, Nashville, Tennessee., Lahiri S; Cedars Sinai Medical Center, Los Angeles, California., Larsson L; Center for Molecular Medicine, Karolinska Institute, Solna, Sweden.; Department of Physiology & Pharmacology, Karolinska Institute and Viron Molecular Medicine Institute, Boston, Massachusetts., Sevin CM; Vanderbilt University School of Medicine, Nashville, Tennessee., Sharshar T; Anesthesia and Intensive Care Department, GHU Paris Psychiatry and Neurosciences, Institute of Psychiatry and Neurosciences of Paris, INSERM U1266, University Paris Cité, Paris, France., Singer B; University of Michigan, Ann Arbor, Michigan., Stevens T; University of South Alabama, Mobile, Alabama., Taylor SP; University of Michigan, Ann Arbor, Michigan., Gomez CR; Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Zhou G; Division of Lung Diseases, National Heart, Lung, and Blood Institute, Bethesda, Maryland., Girard TD; Center for Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Hough CL; Oregon Health & Science University, Portland, Oregon; and.
Jazyk: angličtina
Zdroj: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Jun 01; Vol. 209 (11), pp. 1304-1313.
DOI: 10.1164/rccm.202311-2130WS
Abstrakt: Acute respiratory distress syndrome (ARDS) is associated with long-term impairments in brain and muscle function that significantly impact the quality of life of those who survive the acute illness. The mechanisms underlying these impairments are not yet well understood, and evidence-based interventions to minimize the burden on patients remain unproved. The NHLBI of the NIH assembled a workshop in April 2023 to review the state of the science regarding ARDS-associated brain and muscle dysfunction, to identify gaps in current knowledge, and to determine priorities for future investigation. The workshop included presentations by scientific leaders across the translational science spectrum and was open to the public as well as the scientific community. This report describes the themes discussed at the workshop as well as recommendations to advance the field toward the goal of improving the health and well-being of ARDS survivors.
Databáze: MEDLINE