Microglial Activation and Progression of Nigrostriatal Dysfunction in Isolated REM Sleep Behavior Disorder.

Autor: Stær K; Department of Nuclear Medicine & PET, Aarhus University Hospital, Aarhus, Denmark., Iranzo A; Department of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.; Multidisciplinary Sleep Unit, Hospital Clinic, Barcelona, Spain., Stokholm MG; Department of Nuclear Medicine & PET, Aarhus University Hospital, Aarhus, Denmark.; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark., Hvingelby VS; Department of Nuclear Medicine & PET, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine-Nuclear Medicine and PET, Aarhus University, Aarhus, Denmark., Danielsen EH; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark., Østergaard K; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark., Serradell M; Department of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.; Multidisciplinary Sleep Unit, Hospital Clinic, Barcelona, Spain., Otto M; Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, Denmark., Svendsen KB; Department of Neurology, Aarhus University Hospital, Aarhus, Denmark., Garrido A; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.; Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Spain., Vilas D; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.; Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Spain., Santamaria J; Department of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.; Multidisciplinary Sleep Unit, Hospital Clinic, Barcelona, Spain., Møller A; Department of Nuclear Medicine & PET, Aarhus University Hospital, Aarhus, Denmark., Gaig C; Department of Neurology, Hospital Clínic de Barcelona, Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.; Multidisciplinary Sleep Unit, Hospital Clinic, Barcelona, Spain., Brooks DJ; Department of Nuclear Medicine & PET, Aarhus University Hospital, Aarhus, Denmark.; Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UK., Borghammer P; Department of Nuclear Medicine & PET, Aarhus University Hospital, Aarhus, Denmark., Tolosa E; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.; Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Spain., Pavese N; Department of Nuclear Medicine & PET, Aarhus University Hospital, Aarhus, Denmark.; Translational and Clinical Research Institute, Newcastle University, Newcastle-upon-Tyne, UK.
Jazyk: angličtina
Zdroj: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2024 Aug; Vol. 39 (8), pp. 1323-1328. Date of Electronic Publication: 2024 Mar 13.
DOI: 10.1002/mds.29767
Abstrakt: Background: Using 11 C-(R)-PK11195-PET, we found increased microglia activation in isolated REM sleep behavior disorder (iRBD) patients. Their role remains to be clarified.
Objectives: The objective is to assess relationships between activated microglia and progression of nigrostriatal dysfunction in iRBD.
Methods: Fifteen iRBD patients previously scanned with 11 C-(R)-PK11195 and 18 F-DOPA-PET underwent repeat 18 F-DOPA-PET after 3 years. 18 F-DOPA K i changes from baseline were evaluated with volumes-of-interest and voxel-based analyses.
Results: Significant 18 F-DOPA K i reductions were found in putamen and caudate. Reductions were larger and more widespread in patients with increased nigral microglia activation at baseline. Left nigral 11 C-(R)-PK11195 binding at baseline was a predictor of 18 F-DOPA K i reduction in left caudate (coef = -0.0426, P = 0.016).
Conclusions: Subjects with increased baseline 11 C-(R)-PK11195 binding have greater changes in nigrostriatal function, suggesting a detrimental rather than protective effect of microglial activation. Alternatively, both phenomena occur in patients with prominent nigrostriatal dysfunction without a causative link. The clinical and therapeutic implications of these findings need further elucidation. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
(© 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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