| Autor: |
Alexandrova LA; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov Str., Moscow 119991, Russia., Oskolsky IA; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov Str., Moscow 119991, Russia., Makarov DA; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov Str., Moscow 119991, Russia., Jasko MV; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov Str., Moscow 119991, Russia., Karpenko IL; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov Str., Moscow 119991, Russia., Efremenkova OV; Gause Institute of New Antibiotics, 11 Bol'shaya Pirogovskaya, Moscow 119021, Russia., Vasilyeva BF; Gause Institute of New Antibiotics, 11 Bol'shaya Pirogovskaya, Moscow 119021, Russia., Avdanina DA; Research Center of Biotechnology RAS, 33 Leninsky Ave, Moscow 119071, Russia., Ermolyuk AA; Research Center of Biotechnology RAS, 33 Leninsky Ave, Moscow 119071, Russia., Benko EE; Research Center of Biotechnology RAS, 33 Leninsky Ave, Moscow 119071, Russia., Kalinin SG; Research Center of Biotechnology RAS, 33 Leninsky Ave, Moscow 119071, Russia., Kolganova TV; Research Center of Biotechnology RAS, 33 Leninsky Ave, Moscow 119071, Russia., Berzina MY; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., Moscow 117997, Russia., Konstantinova ID; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., Moscow 117997, Russia., Chizhov AO; Zelinsky Institute of Organic Chemistry RAS 47 Leninsky Ave, Moscow 119991, Russia., Kochetkov SN; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov Str., Moscow 119991, Russia., Zhgun AA; Research Center of Biotechnology RAS, 33 Leninsky Ave, Moscow 119071, Russia. |
| Abstrakt: |
The rapid increase in the antibiotic resistance of microorganisms, capable of causing diseases in humans as destroying cultural heritage sites, is a great challenge for modern science. In this regard, it is necessary to develop fundamentally novel and highly active compounds. In this study, a series of N 4 -alkylcytidines, including 5- and 6-methylcytidine derivatives, with extended alkyl substituents, were obtained in order to develop a new generation of antibacterial and antifungal biocides based on nucleoside derivatives. It has been shown that N 4 -alkyl 5- or 6-methylcytidines effectively inhibit the growth of molds, isolated from the paintings in the halls of the Ancient Russian Paintings of the State Tretyakov Gallery, Russia, Moscow. The novel compounds showed activity similar to antiseptics commonly used to protect works of art, such as benzalkonium chloride, to which a number of microorganisms have acquired resistance. It was also shown that the activity of N 4 -alkylcytidines is comparable to that of some antibiotics used in medicine to fight Gram-positive bacteria, including resistant strains of Staphylococcus aureus and Mycobacterium smegmatis . N 4 -dodecyl-5- and 6-methylcytidines turned out to be the best. This compound seems promising for expanding the palette of antiseptics used in painting, since quite often the destruction of painting materials is caused by joint fungi and bacteria infection. |
