A Review: Biomechanical Aspects of the Fallopian Tube Relevant to its Function in Fertility.

Autor: Seraj H; School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran., Nazari MA; School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran. manazari@ut.ac.ir.; Department of Speech and Cognition, CNRS UMR 5216, Grenoble Institute of Technology, Grenoble, France. manazari@ut.ac.ir., Atai AA; School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran., Amanpour S; Vali-E-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran.; Cancer Biology Research Center, Tehran University of Medical Sciences, Tehran, Iran., Azadi M; School of Engineering, College of Science and Engineering, San Francisco State University, San Francisco, CA, USA. azadi@sfsu.edu.
Jazyk: angličtina
Zdroj: Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] 2024 Jun; Vol. 31 (6), pp. 1456-1485. Date of Electronic Publication: 2024 Mar 12.
DOI: 10.1007/s43032-024-01479-x
Abstrakt: The fallopian tube (FT) plays a crucial role in the reproductive process by providing an ideal biomechanical and biochemical environment for fertilization and early embryo development. Despite its importance, the biomechanical functions of the FT that originate from its morphological aspects, and ultrastructural aspects, as well as the mechanical properties of FT, have not been studied nor used sufficiently, which limits the understanding of fertilization, mechanotrasduction, and mechanobiology during embryo development, as well as the replication of the FT in laboratory settings for infertility treatments. This paper reviews and revives valuable information on human FT reported in medical literature in the past five decades relevant to the biomechanical aspects of FT. In this review, we summarized the current state of knowledge concerning the morphological, ultrastructural aspects, and mechanical properties of the human FT. We also investigate the potential arising from a thorough consideration of the biomechanical functions and exploring often neglected mechanical aspects. Our investigation encompasses both macroscopic measurements (such as length, diameter, and thickness) and microscopic measurements (including the height of epithelial cells, the percentage of ciliated cells, cilia structure, and ciliary beat frequency). Our primary focus has been on healthy women of reproductive age. We have examined various measurement techniques, encompassing conventional metrology, 2D histological data as well as new spatial measurement techniques such as micro-CT.
(© 2024. The Author(s), under exclusive licence to Society for Reproductive Investigation.)
Databáze: MEDLINE
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