Pathophysiology and clinical relevance of atrial myopathy.

Autor: Tubeeckx MRL; Laboratory of Physiopharmacology, Universiteitsplein 1, Building T (2nd Floor), 2610, Antwerp, Belgium. michiel.tubeeckx@uantwerpen.be., De Keulenaer GW; Laboratory of Physiopharmacology, Universiteitsplein 1, Building T (2nd Floor), 2610, Antwerp, Belgium.; Department of Cardiology, ZNA Middelheim Hospital Antwerp, Antwerp, Belgium., Heidbuchel H; Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, Antwerp, Belgium.; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium., Segers VFM; Laboratory of Physiopharmacology, Universiteitsplein 1, Building T (2nd Floor), 2610, Antwerp, Belgium.; Department of Cardiology, University Hospital Antwerp, Antwerp, Belgium.
Jazyk: angličtina
Zdroj: Basic research in cardiology [Basic Res Cardiol] 2024 Apr; Vol. 119 (2), pp. 215-242. Date of Electronic Publication: 2024 Mar 12.
DOI: 10.1007/s00395-024-01038-0
Abstrakt: Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria and is the substrate for development of atrial fibrillation, the most common arrhythmia. Pathophysiologic mechanisms driving atrial myopathy are inflammation, oxidative stress, atrial stretch, and neurohormonal signals, e.g., angiotensin-II and aldosterone. These mechanisms initiate the structural and functional remodeling of the atrial myocardium. Novel therapeutic strategies are being developed that target the pathophysiologic mechanisms of atrial myopathy. In this review, we will discuss the pathophysiology of atrial myopathy, as well as diagnostic and therapeutic strategies.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.)
Databáze: MEDLINE
Externí odkaz: