CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan.

Autor: Lim SYM; Division of Biomedical Sciences, School of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia.; Faculty of Business, Design and Arts, Swinburne University of Technology, Kuching, Sarawak, Malaysia., Pan Y; Division of Biomedical Sciences, School of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia., Alshagga M; Division of Biomedical Sciences, School of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia., Lim W; Faculty of Engineering, Computing and Science, Swinburne University of Technology, Kuching, Sarawak, Malaysia., Cin K; Division of Biomedical Sciences, School of Pharmacy, University of Nottingham Malaysia, Semenyih, Selangor, Malaysia., Alshehade SA; Faculty of Pharmacy & Bio-Medical Sciences, MAHSA University, Selangor, Malaysia., Alshawsh M; Department of Pharmacology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.; School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia.
Jazyk: angličtina
Zdroj: Journal of applied toxicology : JAT [J Appl Toxicol] 2024 Mar 12. Date of Electronic Publication: 2024 Mar 12.
DOI: 10.1002/jat.4597
Abstrakt: CYP-14 members of the Caenorhabditis elegans (C. elegans) Cytochrome P450 (CYP) enzyme family, plays important roles in mitochondrial dysfunction, detoxification, lipid metabolism, defense and lifespan regulation. The review identifies CYP-14 members: cyp-14A1, cyp-14A2, cyp-14A3, cyp-14A4, cyp-14A5 and their homology with human CYP families. Despite limited studies on C. elegans cyp-14 members, the findings unraveled their complex crosstalk between mitochondrial stress, detoxification mechanisms, and lifespan regulation, emphasizing the complexity of these interconnected pathways as well as how their regulation depends on environmental cues changes including pH, nutrients, ROS and chemical stressors. The review underscores the translational relevance to human health, shedding light on potential human homologues and their implications in age-related, metabolic and respiratory diseases. Among other genes, cyp-14A2 and cyp-14A4 predominate the mitochondrial function, heat resistance, lipid metabolism, detoxification and lifespan pathways. In conclusion, these insights pave the way for future research, offering promising avenues for therapeutic interventions targeting CYP-14 activity to address age-related diseases and promote healthy aging.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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