Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice.

Autor:	Witmer NH; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Molecular Medicine Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Linzer CR; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Boudreau RL; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Molecular Medicine Graduate Program, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center and Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: ryan-boudreau@uiowa.edu.
Jazyk:	angličtina
Zdroj:	Cell metabolism [Cell Metab] 2024 May 07; Vol. 36 (5), pp. 879-881. Date of Electronic Publication: 2024 Mar 11.
DOI:	10.1016/j.cmet.2024.02.008
Abstrakt:	Witmer et al. provide genomic and molecular evidence to demonstrate that Fndc5 (irisin myokine precursor protein) is translated in humans from an overlooked upstream ATG codon. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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